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Interstitial Cells of Cajal and Enteric Nervous System in Gastrointestinal and Neurological Pathology, Relation to Oxidative Stress

2023Journal article Open access
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dc.contributor.authorLópez-Pingarrón, L
dc.contributor.authorAlmeida, H
dc.contributor.authorSoria-Aznar, M
dc.contributor.authorReyes-Gonzales, MC
dc.contributor.authorRodríguez-Moratinos, AB
dc.contributor.authorMuñoz-Hoyos, A
dc.contributor.authorGarcía, JJ
dc.date.accessioned2023-05-22T10:35:28Z
dc.date.available2023-05-22T10:35:28Z
dc.date.issued2023
dc.description.abstractThe enteric nervous system (ENS) is organized into two plexuses-submucosal and myenteric-which regulate smooth muscle contraction, secretion, and blood flow along the gastrointestinal tract under the influence of the rest of the autonomic nervous system (ANS). Interstitial cells of Cajal (ICCs) are mainly located in the submucosa between the two muscle layers and at the intramuscular level. They communicate with neurons of the enteric nerve plexuses and smooth muscle fibers and generate slow waves that contribute to the control of gastrointestinal motility. They are also involved in enteric neurotransmission and exhibit mechanoreceptor activity. A close relationship appears to exist between oxidative stress and gastrointestinal diseases, in which ICCs can play a prominent role. Thus, gastrointestinal motility disorders in patients with neurological diseases may have a common ENS and central nervous system (CNS) nexus. In fact, the deleterious effects of free radicals could affect the fine interactions between ICCs and the ENS, as well as between the ENS and the CNS. In this review, we discuss possible disturbances in enteric neurotransmission and ICC function that may cause anomalous motility in the gut.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCurr Issues Mol Biol . 2023 Apr 18;45(4):3552-3572.pt_PT
dc.identifier.doi10.3390/cimb45040232pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/44835
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectSistema Nervoso Entéricopt_PT
dc.subjectTrato Gastrointestinal/inervaçãopt_PT
dc.subjectStress Oxidativopt_PT
dc.subjectEnteric Nervous Systempt_PT
dc.subjectGastrointestinal Tract/innervationpt_PT
dc.subjectOxidative Stresspt_PT
dc.titleInterstitial Cells of Cajal and Enteric Nervous System in Gastrointestinal and Neurological Pathology, Relation to Oxidative Stresspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3572pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage3552pt_PT
oaire.citation.titleCurrent Issues in Molecular Biologypt_PT
oaire.citation.volume45pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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