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Reclassification of the intermediate group classified according to heartscore taking in considertaion individual genetic predisposition to coronary artery disease

2017Conference object Open access
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dc.contributor.authorMendonça, M.
dc.contributor.authorPereira, A.
dc.contributor.authorRodrigues, R.
dc.contributor.authorNeto, M.
dc.contributor.authorSousa, A.C.
dc.contributor.authorFreitas, S.
dc.contributor.authorFreitas, C.
dc.contributor.authorFreitas, A.I.
dc.contributor.authorBorges, S.
dc.contributor.authorPalma dos Reis, R.
dc.date.accessioned2020-03-03T12:35:02Z
dc.date.available2020-03-03T12:35:02Z
dc.date.issued2017
dc.descriptionPosterpt_PT
dc.description.abstractIntroduction: Cardiovascular risk stratification has included traditional cardiovascular risk factors (TRF) including tobacco, cholesterol and blood pressure adjusted to age and sex. The utility of genetic risk scores (GRS) as predictors of cardiovascular risk remains inconclusive. Objective: We intended to evaluate the ability of a multilocus GRS within the intermediate risk subgroup, defined by the European Heart score, to add predictive power for the association with coronary artery arterial disease (CAD). Methods: After applying European SCORE (ES) stratification to a total population of 2703 Portuguese individuals, 639 individuals with 59.0 ± 4.3 years were considered to be at intermediate risk subgroup (2<es<9).> Results: GRS was an independent predictor for CAD (OR=2.411; p<0.0001). Diabetes mellitus (OR=3.196;p<0.0001), arterial hypertension (OR=2.201; p=0.003) and smoking (OR=3.148; p<0.0001) were also significantly associated with CAD. AUC increased from 0.694 to 0.734 after adding GRS to TRF. When discriminated by tertiles of GRS, the AUC for TRF was maximum for the 2nd tertile GRS [AUC (TRF)=0.734] and lower for the 1st and 3rd tertiles (AUC =0.673 and AUC =0.671, respectively). NRI showed better increase in the intermediate risk subgroup with a 35.2% interpreted as the roportion of patients reclassified to a more appropriate risk category, and 29.4% on the lower risk. Conclusion: In our population, the GRS increased the predictive value of TRF in the subgroup of patients at intermediate risk by the European Score. The predictive value of TRF is lower in patients with higher GRS. In this subgroup, the inclusion of genotyping may be considered for better stratification of cardiovascular risk. </es<9).>pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRisk factors: others. (2017). European Journal of Preventive Cardiology, 24(1_suppl), S158–S171. https://doi.org/10.1177/2047487317703555pt_PT
dc.identifier.doihttps://doi.org/10.1177/2047487317703555pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/31572
dc.language.isoengpt_PT
dc.subjectreclassificationpt_PT
dc.subjectgenetic predispositionpt_PT
dc.subjectcoronary artery diseasept_PT
dc.subjectPortugalpt_PT
dc.subjectMadeira Islandpt_PT
dc.subjectheartscorept_PT
dc.subjectdoença coronáriapt_PT
dc.titleReclassification of the intermediate group classified according to heartscore taking in considertaion individual genetic predisposition to coronary artery diseasept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPageS171pt_PT
oaire.citation.issue1_supplpt_PT
oaire.citation.startPageS158pt_PT
oaire.citation.titleEuropean Journal of Preventive Cardiologypt_PT
oaire.citation.volume24pt_PT
person.familyNameMendonca
person.familyNamepereira
person.familyNameRodrigues
person.familyNameSousa
person.familyNameFreitas
person.familyNameBorges
person.familyNameReis
person.givenNameMaria Isabel
person.givenNameandreia
person.givenNameRicardo C.
person.givenNameAna Célia
person.givenNameSónia
person.givenNameSofia
person.givenNameRoberto
person.identifier.orcid0000-0001-5450-5213
person.identifier.orcid0000-0001-5129-2478
person.identifier.orcid0000-0002-5115-6991
person.identifier.orcid0000-0002-2069-0278
person.identifier.orcid0000-0001-5204-8928
person.identifier.orcid0000-0002-9413-7942
person.identifier.orcid0000-0003-2803-8193
person.identifier.scopus-author-id57189234203
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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