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Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugal

2025Journal article Open access
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dc.contributor.authorFevereiro-Martins, M
dc.contributor.authorAguiar, L
dc.contributor.authorInácio, Â
dc.contributor.authorCardoso, C
dc.contributor.authorSantos, AC
dc.contributor.authorMarques-Neves, C
dc.contributor.authorGuimarães, H
dc.contributor.authorPinto, R
dc.contributor.authorBicho, M
dc.date.accessioned2025-02-06T22:51:13Z
dc.date.available2025-02-06T22:51:13Z
dc.date.issued2025
dc.description.abstractBackground/Objectives: Retinopathy of prematurity (ROP) is a leading cause of vision impairment in preterm infants, with its pathogenesis linked to oxygen exposure. Red blood cell (RBC) transfusions, commonly performed in neonatal intensive care units (NICUs), reduce fetal hemoglobin (HbF) fraction, altering oxygen dynamics and potentially contributing to ROP. We aimed to investigate the relationship between RBC transfusions, HbF percentage, and ROP, evaluating HbF as a potential predictive biomarker. Methods: A multicenter, prospective study was conducted across eight Portuguese NICUs, involving infants born at <32 weeks gestational age (GA) or <1500 g. ROP staging followed the International Classification of ROP (ICROP2). Clinical data were collected during hospitalization, and HbF fractions were measured from blood samples in the first four weeks of life using standardized methods. Infants were stratified by ROP presence and treatment requirement. Statistical analysis was performed using SPSS 28.0, with p < 0.05. Results: Eighty-two infants (mean GA: 28.1 ± 2.1 weeks, birth weight: 1055.8 ± 258.3 g) were included. Among them, 29 (35.4%) presented ROP and 4 (4.9%) required treatment. Infants with ROP had more RBC transfusions and lower HbF percentages than those without ROP (p < 0.05). Lower HbF was associated with more RBC transfusions (p < 0.001). Kaplan-Meier survival curves showed a higher ROP risk in infants with reduced HbF (p < 0.05). Conclusions: Low HbF percentage in the first four weeks of life may increase ROP risk in preterm infants. HbF could serve as a biomarker for ROP prediction. Interventions preserving HbF may reduce ROP risk. Further studies are needed to validate HbF as a biomarker and refine prevention strategies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiomedicines . 2025 Jan 6;13(1):110.pt_PT
dc.identifier.doi10.3390/biomedicines13010110pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/54277
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHemoglobina Fetalpt_PT
dc.subjectRetinopatia da Prematuridadept_PT
dc.subjectBiomarcadores/sanguept_PT
dc.subjectFetal Hemoglobinpt_PT
dc.subjectRetinopathy of Prematuritypt_PT
dc.subjectBiomarkers/bloodpt_PT
dc.titleFetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage110pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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