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Inflammatory bowel disease, alpha-synuclein aggregates and Parkinson’s disease: the InflamaSPark protocol

2021Other Open access
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dc.contributor.authorGrunho, Miguel
dc.contributor.authorGodinho, Catarina
dc.contributor.authorPatita, Marta
dc.contributor.authorMocanu, Irina
dc.contributor.authorVieira, Ana Isabel
dc.contributor.authorDe Matos, António
dc.contributor.authorCarregosa, Ricardo
dc.contributor.authorMarx, Frederico
dc.contributor.authorTomé, Morgane
dc.contributor.authorSousa-Catita, Diogo
dc.contributor.authorProença, Luís
dc.contributor.authorOuteiro, Tiago
dc.contributor.authorFonseca, Jorge
dc.date.accessioned2022-04-05T13:35:22Z
dc.date.available2022-04-05T13:35:22Z
dc.date.issued2021
dc.descriptionCommunication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.pt_PT
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractThe hallmark of Parkinson’s disease (PD) is the accumulation of alpha-synuclein (AS) aggregates. Prior to the central nervous system involvement, PD establishes itself in the gut as a result of the complex interplay between microbiota, the host’s immune/neural systems and increased intestinal permeability. Inflammatory Bowel Disease (IBD) patients present a higher number of AS aggregates in the intestinal wall and an increased risk of developing PD. By studying AS aggregates in gut biopsy specimens of IBD patients and controls, this project aims to further clarify the pathophysiology of PD and to explore the potential of gut a biopsy for AS aggregates as a biomarker for prodromal PD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGrunho M, Godinho C, Patita M, Mocanu I, Vieira AI, de Matos AA, Carregosa R, Marx F, Tomé M, Sousa-Catita D, Proença L, Outeiro T, Fonseca J. Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson’s Disease: The InflamaSPark Protocol. Medical Sciences Forum. 2021; 5(1):28. https://doi.org/10.3390/msf2021005028pt_PT
dc.identifier.doi10.3390/msf2021005028pt_PT
dc.identifier.issn2673-9992
dc.identifier.urihttp://hdl.handle.net/10400.26/40113
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/msf2021005028pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectinflammatory bowel diseasept_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectgut alpha-synuclein aggregatespt_PT
dc.titleInflammatory bowel disease, alpha-synuclein aggregates and Parkinson’s disease: the InflamaSPark protocolpt_PT
dc.typeother
dspace.entity.typePublication
oaire.citation.startPage28pt_PT
oaire.citation.titleMedical Sciences Forumpt_PT
oaire.citation.volume5(1)pt_PT
person.familyNameDias Grunho
person.familyNameGodinho
person.familyNameMatos
person.familyNameProença
person.familyNameFonseca
person.givenNameMiguel
person.givenNameCatarina
person.givenNameAntonio
person.givenNameLuis
person.givenNameJorge
person.identifierABF-6650-2020
person.identifierN-6604-2013
person.identifier.ciencia-id421E-1273-70CD
person.identifier.ciencia-id3919-33C7-AAF3
person.identifier.ciencia-idD91B-1F12-E2C4
person.identifier.ciencia-idC01D-DE3F-3C63
person.identifier.ciencia-id0217-4780-74BC
person.identifier.orcid0000-0002-5529-7695
person.identifier.orcid0000-0003-2304-3129
person.identifier.orcid0000-0001-9386-0349
person.identifier.orcid0000-0002-8482-5936
person.identifier.orcid0000-0001-6477-7028
person.identifier.ridA-4539-2013
person.identifier.scopus-author-id7004834739
person.identifier.scopus-author-id6603543544
rcaap.rightsopenAccesspt_PT
rcaap.typeotherpt_PT
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