Main Determinants of PON1 Activity in Hemodialysis Patients

Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 activity in HD patients is poorly clarified. Our aim was to evaluate the influence of two polymorphisms and non-genetic factors on PON1 activity in HD patients.

Keywords

Adiponectin Aged Aged, 80 and over Anemia Aryldialkylphosphatase Biomarkers C-Reactive Protein Enzyme Activation Erythropoietin Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Inflammation Interleukin-6 Kidney Failure, Chronic Lipids Male Middle Aged Polymorphism, Genetic Prognosis Risk Factors Renal Dialysis Madeira Island Portugal