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IgA dominant glomerulonephritis associated to staphylococcus infection: a peculiar case report

2019Journal article Open access
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dc.contributor.authorPestana, Nicole
dc.contributor.authorVieira, Pedro
dc.contributor.authorSilva, Francisca
dc.contributor.authorFigueira, José Ricardo
dc.contributor.authorSilva, Gil
dc.contributor.authorDurães, José
dc.date.accessioned2019-08-29T15:59:40Z
dc.date.available2019-08-29T15:59:40Z
dc.date.issued2019
dc.description.abstractIgA dominant glomerulonephritis associated to Staphylococcus infection is a rare clinical entity that has been described mainly in case reports. Biopsy features can resemble other disease entities mainly IgA nephropathy and Henoch‑Schönlein purpura nephritis. Treatment of IgA dominant glomerulonephritis associated to staphylococcal infection is based on antibiotics for the underlying infection, controlling hypertension and edema and may resort to concomitant use of steroids in selected cases. Prognosis markers such as hypertension, diabetes and interstitial fibrosis may influence treatment as they are associated with poor renal outcomes. We report a case of a 63‑year‑old man with known hypertension, pre‑diabetes and recent history of methicillin‐sensitive staphylococcus aureus bacteremia associated to prostatitis, who presented with a one‑month history of edema, arthralgia and foamy urine. Over this period he progressed to anasarca and nephrotic range proteinuria with concomitant rise in creatinine levels being documented. The renal biopsy showed segmental endocapillary proliferation and IgA segmental dominant staining associated to C3 and lambda in minor distribution. On completion of two months of steroid therapy the patient partially recovered his renal function and proteinuria. After nine months of tapering steroids, he presented with acute inflammatory arthritis supporting an inflammatory background disease. To our knowledge this case describes an unusual entity such as IgA dominant glomerulonephritis associated to staphylococcal infection co‑presenting with an associated reactive arthritis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPort J Nephrol Hypert 2019; 33(2): 122-125 • Advance Access publication 1 July 2019pt_PT
dc.identifier.doidoi.org/10.32932/pjnh.2019.07.025pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/29598
dc.language.isospapt_PT
dc.relation.publisherversionhttps://www.researchgate.net/publication/334262479pt_PT
dc.subjectIgA nephropathypt_PT
dc.subjectStaphylococcuspt_PT
dc.subjectPostinfectious glomerulonephritispt_PT
dc.subjectPortugalpt_PT
dc.titleIgA dominant glomerulonephritis associated to staphylococcus infection: a peculiar case reportpt_PT
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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