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The protective role of adiponectin for lipoproteins in end-stage renal disease patients: relationship with diabetes and body mass index

2019Journal article Open access
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dc.contributor.authorCoimbra, Susana
dc.contributor.authorReis, Flávio
dc.contributor.authorNunes, Sara
dc.contributor.authorViana, Sofia
dc.contributor.authorValente, Maria João
dc.contributor.authorRocha, Susana
dc.contributor.authorCatarino, Cristina
dc.contributor.authorRocha-Pereira, Petronila
dc.contributor.authorBronze-da-Rocha, Elsa
dc.contributor.authorSameiro-Faria, Maria
dc.contributor.authorOliveira, José Gerardo
dc.contributor.authorMadureira, José
dc.contributor.authorFernandes, João Carlos
dc.contributor.authorMiranda, Vasco
dc.contributor.authorBelo, Luís
dc.contributor.authorSantos-Silva, Alice
dc.date.accessioned2020-04-11T14:49:31Z
dc.date.available2020-04-11T14:49:31Z
dc.date.issued2019
dc.description.abstractCardiovascular disease (CVD) events are the main causes of death in end-stage renal disease (ESRD) patients on dialysis. The number and severity of CVD events remain inappropriate and difficult to explain by considering only the classic CVD risk factors. Our aim was to clarify the changes and the relationship of lipoprotein subfractions with other CVD risk factors, namely, body mass index (BMI) and adipokines, inflammation and low-density lipoprotein (LDL) oxidation, and the burden of the most prevalent comorbidities, diabetes mellitus (DM) and hypertension (HT). We studied 194 ESRD patients on dialysis and 22 controls; lipid profile, including lipoprotein subpopulations and oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, leptin, and paraoxonase 1 activity were evaluated. Compared to controls, patients presented significantly lower levels of cholesterol, high-density lipoprotein cholesterol (HDLc), LDLc, oxLDL, and intermediate and small HDL and higher triglycerides, CRP, adiponectin, large HDL, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein- (IDL) B. Adiponectin levels correlated positively with large HDL and negatively with intermediate and small HDL, oxLDL/LDLc, and BMI; patients with DM (n = 17) and with DM+HT (n = 70), as compared to patients without DM or HT (n = 69) or only with HT (n = 38), presented significantly higher oxLDL, oxLDL/LDLc, and leptin and lower adiponectin. Obese patients (n = 45), as compared to normoponderal patients (n = 81), showed lower HDLc, adiponectin, and large HDL and significantly higher leptin, VLDL, and intermediate and small HDL. In ESRD, the higher adiponectin seems to favor atheroprotective HDL modifications and protect LDL particles from oxidative atherogenic changes. However, in diabetic and obese patients, adiponectin presents the lowest values, oxLDL/LDLc present the highest ones, and the HDL profile is the more atherogenic. Our data suggest that the coexistence of DM and adiposity in ESRD patients on dialysis contributes to a higher CVD risk, as showed by their lipid and adipokine profiles.pt_PT
dc.description.sponsorshipPOCI/01/0145/FEDER/007728), and North Portugal Regional Coordination and Development Commission (CCDR-N)/NORTE2020/Portugal 2020 (Norte-01-0145- FEDER-000024).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1155/2019/3021785pt_PT
dc.identifier.issn1942-0900
dc.identifier.urihttp://hdl.handle.net/10400.26/31979
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationApplied Molecular Biosciences Unit
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAdiponectinpt_PT
dc.subjectDiabetes Mellituspt_PT
dc.subjectHumanspt_PT
dc.subjectKidney Failure, Chronicpt_PT
dc.subjectLipoproteinspt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectAdiponectinapt_PT
dc.subjectHumanospt_PT
dc.subjectFalência renal crónicapt_PT
dc.subjectLipoproteínaspt_PT
dc.subjectÍndice de massa corporalpt_PT
dc.titleThe protective role of adiponectin for lipoproteins in end-stage renal disease patients: relationship with diabetes and body mass indexpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleOxidative Medicine and Cellular Longevitypt_PT
oaire.citation.volume2019pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMeireles Coimbra
person.familyNameNunes
person.familyNameViana
person.familyNamede Sá Viana Sampaio e Melo Valente
person.familyNameRocha
person.familyNameCatarino
person.familyNameRocha-Pereira
person.familyNameBronze da Rocha
person.familyNamede Pina Aresta Branco Miranda
person.familyNameSantos-Silva
person.givenNameCarla Susana
person.givenNameSara
person.givenNameSofia
person.givenNameMaria João
person.givenNameSusana
person.givenNameCristina
person.givenNamePetronila
person.givenNameElsa
person.givenNameVasco
person.givenNameAlice
person.identifierB-3313-2017
person.identifier.ciencia-id1818-39C9-ECC9
person.identifier.ciencia-id131C-F496-B174
person.identifier.ciencia-id521B-B11C-CCC3
person.identifier.ciencia-id271E-1935-B059
person.identifier.ciencia-id0D13-E5DE-384A
person.identifier.ciencia-id5210-C4D2-93CE
person.identifier.ciencia-idC212-09D7-EC3A
person.identifier.ciencia-id2C1B-EEA6-BFBE
person.identifier.ciencia-id3A11-3945-4DC4
person.identifier.orcid0000-0001-8411-8038
person.identifier.orcid0000-0003-2944-306X
person.identifier.orcid0000-0002-1316-1319
person.identifier.orcid0000-0002-6137-5995
person.identifier.orcid0000-0002-8001-1898
person.identifier.orcid0000-0002-3229-1434
person.identifier.orcid0000-0002-7985-1494
person.identifier.orcid0000-0002-3571-2513
person.identifier.orcid0000-0002-2565-3169
person.identifier.ridK-5492-2013
person.identifier.ridK-3102-2013
person.identifier.ridK-2723-2013
person.identifier.ridK-2326-2013
person.identifier.scopus-author-id54416082400
person.identifier.scopus-author-id55353634200
person.identifier.scopus-author-id54382399000
person.identifier.scopus-author-id23984221900
person.identifier.scopus-author-id55891444400
person.identifier.scopus-author-id7801393706
person.identifier.scopus-author-id6603836490
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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