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Validation of two spectrophotometric methods for fluoxetine quantification

dc.contributor.authorGaspar, Joana
dc.contributor.authorBarbosa Moreira, Zélia
dc.date.accessioned2022-12-27T12:38:57Z
dc.date.available2022-12-27T12:38:57Z
dc.date.issued2016-03
dc.description.abstractObjective: This paper describes the development and validation of two UV-Visible spectrophotometric analysis methods, using absolute ethanol (method A) and HCl 0.1 M (method B) as solvents, to quantify fluoxetine (FLX) in its generic and brand name form. The objective is to validate both methods and compare the concentrations of the samples obtained from each one. Methods: Validation of each method with the determination of linearity, limit of detection and quantification, intermediary precision, robustness, accuracy and uniformity of mass for both samples was performed. Results: Uniform distribution of FLX in capsules were verified and good linear relationships were found between the readings and the concentrations of FLX, in the ranges of 100 μg/ml to 300 μg/ml and 5 μg/ml to 25 μg/ml, for method A and B, respectively. The limit of quantification obtained was 9.96 μg/ml for method A and 0.87 μg/ml for method B. The limit of detection obtained was 2.988 μg/ml for method A and 0.26 μg/ml for method B. Was also verified robustness, good inter-day precision and accuracy of both methods. Conclusion: The methods were successfully validated to the determination of FLX in its pharmaceutical formulations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGaspar, Joana Moreira, Zelia. (2016). VALIDATION OF TWO SPECTROPHOTOMETRIC METHODS FOR FLUOXETINE QUANTIFICATION. International Journal of Pharmacy and Pharmaceutical Sciences. 8. 72-78.pt_PT
dc.identifier.issn0975-1491
dc.identifier.urihttp://hdl.handle.net/10400.26/42883
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInnovare Academic Sciencespt_PT
dc.relation.publisherversionhttps://www.researchgate.net/publication/298429606_VALIDATION_OF_TWO_SPECTROPHOTOMETRIC_METHODS_FOR_FLUOXETINE_QUANTIFICATIONpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectFluoxetinept_PT
dc.subjectUV-Visible spectrophotometrypt_PT
dc.subjectQuantificationpt_PT
dc.subjectValidationpt_PT
dc.subjectFluoxetinapt_PT
dc.subjectEspectrofotometria UVpt_PT
dc.subjectQuantificaçãopt_PT
dc.subjectValidaçãopt_PT
dc.titleValidation of two spectrophotometric methods for fluoxetine quantificationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage78pt_PT
oaire.citation.startPage72pt_PT
oaire.citation.titleInternational Journal of Pharmacy and Pharmaceutical Sciencespt_PT
oaire.citation.volume8pt_PT
person.familyNameBarbosa Moreira
person.givenNameZélia
person.identifier.ciencia-id5213-E9A1-3FC5
person.identifier.orcid0000-0002-7527-1361
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7edc1e73-ebd5-4f58-8574-38a40a4496f5
relation.isAuthorOfPublication.latestForDiscovery7edc1e73-ebd5-4f58-8574-38a40a4496f5

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