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GC-MS – Still standing for clinical and forensic analysis: validation of a multidrug method to detect and quantify illicit drugs

2021-08-11Journal article Open access
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dc.contributor.authorFerreira, Ana Beatriz
dc.contributor.authorCastro, André Lobo
dc.contributor.authorTarelho, Sónia
dc.contributor.authorRodrigues, Pedro
dc.contributor.authorFranco, João Miguel
dc.date.accessioned2023-02-09T12:44:37Z
dc.date.available2023-02-09T12:44:37Z
dc.date.issued2021-08-11
dc.description.abstractAn SPE-GC-MS analytical method using whole blood samples has been developed and validated to detect and quantify nineteen compounds belonging to the Drugs of Abuse (DA) groups of cocaine and metabolites, opiates and new psychoactive substances (NPS). The method detailed here is necessary because the recreational consumption of these DA has increased considerably in recent years and poly-drug-consumption is now very common. The method developed was both specific and selective. Three different working ranges have been defined due to the differences between therapeutic, toxic and lethal concentrations of DA. Linearity was confirmed for the defined working ranges of all DA, except pseudoephedrine, ephedrine, norephedrine, and TFMPP. Since the remaining nineteen substances showed heteroscedasticity, six ponderation factors were studied to find the best fit for each compound. Limits of Detection and Lower Limits of Quantification have been studied and defined. No carryover was noted, with acceptable extraction recoveries. The achievement of all validation criteria according to international guidelines allows the application of the proposed method in routine forensic analysis. Using this method can also significantly reduce response times and GC-MS analysis costs.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationAna Beatriz Ferreira, André Lobo Castro, Sónia Tarelho, Pedro Domingues & João Miguel Franco (2023) GC-MS – Still standing for clinical and forensic analysis: validation of a multidrug method to detect and quantify illicit drugs, Australian Journal of Forensic Sciences, 55:1, 107-128pt_PT
dc.identifier.doi10.1080/00450618.2021.1964598pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/43757
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/00450618.2021.1964598pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectForensic Toxicologypt_PT
dc.subjectmulti-drug methodpt_PT
dc.subjectCocainept_PT
dc.subjectOpiatespt_PT
dc.subjectNew psychoactive substancespt_PT
dc.subjectGC-MSpt_PT
dc.subjectSolid-Phase Extractionpt_PT
dc.titleGC-MS – Still standing for clinical and forensic analysis: validation of a multidrug method to detect and quantify illicit drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage128pt_PT
oaire.citation.startPage107pt_PT
oaire.citation.titleAustralian Journal of Forensic Sciencespt_PT
oaire.citation.volume55pt_PT
person.familyNameLobo Castro
person.familyNameTarelho
person.familyNameFranco
person.givenNameAndré
person.givenNameSónia
person.givenNameJoão
person.identifier.orcid0000-0002-7258-8523
person.identifier.orcid0000-0001-8366-6702
person.identifier.orcid0000-0002-3268-3841
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfedcfeb0-e610-4375-aa1e-5ac1fa74cd28
relation.isAuthorOfPublication631cbcb7-4c75-4fc1-b4cf-8445d428f1de
relation.isAuthorOfPublication045c4125-1313-445f-b05f-b7f204886052
relation.isAuthorOfPublication.latestForDiscoveryfedcfeb0-e610-4375-aa1e-5ac1fa74cd28

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