Repository logo
 
Publication

El síndrome de Mauriac todavía existe

dc.contributor.authorDias, J
dc.contributor.authorMartins, S
dc.contributor.authorCarvalho, S
dc.contributor.authorMarques, O
dc.contributor.authorAntunes, A
dc.date.accessioned2013-04-05T13:27:41Z
dc.date.available2013-04-05T13:27:41Z
dc.date.issued2013
dc.description.abstractBACKGROUND/OBJECTIVE: Mauriac syndrome (MS) is a rare complication of type 1 diabetes mellitus (DM1). It is related to low insulin concentrations and is less common since longer-acting insulins became available. It is characterized by hepatomegaly, growth and puberty delay, and the presence of elevated transaminases and serum lipids. The aim of this study was to describe the patients from a pediatric diabetic population that fulfill the criteria of MS. MATERIALS AND METHODS: A retrospective analysis of the pediatric diabetic population with diagnostic criteria of MS currently followed at Hospital de Braga, was performed. RESULTS: From a population of 91 patients with DM1 18 years, 6 patients with the criteria for MS were identified: 5 girls, and 1 boy. The age at presentation was 13-17 years, with a minimum interval between DM1 diagnosis and MS criteria of 4 years. All the patients were prescribed intensive insulin therapy (median daily insulin dose: 0.88U/kg). All had a previous history of poor glycemic control before the diagnosis of MS with glycated hemoglobin (HbA1c) between 8.8 and 12.9%. Increase of hepatic enzymes was present in all the patients; 4 of them had associated hepatomegaly. All the girls presented puberty delay and cushingoid features. None of the patients presented short stature and 5 of them presented mixed dyslipidemia. CONCLUSIONS: Although MS is an ancient entity described in DM1, it still exists, particularly in adolescent females. Being aware of MS is of extreme importance since most of the clinical features are reversible with better glycemic control.por
dc.identifier.citationEndocrinol Nutr. 2013 Mar 26. pii: S1575-0922(13)00043-0por
dc.identifier.urihttp://hdl.handle.net/10400.26/3877
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectDiabetes Mellitus Tipo 1por
dc.subjectDwarfismopor
dc.subjectPerturbações do Crescimentopor
dc.subjectCriançapor
dc.titleEl síndrome de Mauriac todavía existepor
dc.title.alternativeMauriac syndrome still existspor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
El síndrome de Mauriac todavía existe.pdf
Size:
174.99 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.82 KB
Format:
Item-specific license agreed upon to submission
Description: