Publication
Epstein-Barr virus-associated cholestatic hepatitis
| dc.contributor.author | Salva, I | |
| dc.contributor.author | Silva, IV | |
| dc.contributor.author | Cunha, F | |
| dc.date.accessioned | 2014-02-26T22:53:52Z | |
| dc.date.available | 2014-02-26T22:53:52Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Epstein-Barr virus infection is common in children, usually presenting as infectious mononucleosis, including fever, tonsillitis and lymphadenopathy associated with self-resolving increase in transaminases. Cholestasis is rare in children with only a few cases reported but it was described in up to 55% of the adult population affected. We present a case of a 6-year-old boy with fever, vomiting and choluria. The physical examination showed hepatomegaly and jaundice and was otherwise unremarkable. The laboratory studies revealed increased transaminases (aspartate aminotransferase 97 U/L, alanine aminotransferase 166 U/L), hyperbilirubinaemia (total bilirubin 3.2 mg/dL, direct bilirubin 2.89 mg/dL) and increased γ-glutamyl transpeptidase (114 mg/dL). Urine urobilinogen was increased. The abdominal ultrasound showed hepatomegaly. Epstein-Barr viral capsid antibody IgM was positive and IgG was negative. Serological studies for other viruses were negative. We underline the need to consider Epstein-Barr virus in the cholestatic hepatitis differential diagnosis, in order to avoid unnecessary investigations. | por |
| dc.identifier.citation | BMJ Case Rep. 2013; pii: bcr2013202213 | por |
| dc.identifier.doi | 10.1136/bcr-2013-202213 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/5812 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.subject | Epstein-Barr Virus Infections | por |
| dc.subject | Cholestasis, Intrahepatic | por |
| dc.title | Epstein-Barr virus-associated cholestatic hepatitis | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |