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Drug resistance and genetic diversity of Mycobacterium tuberculosis in Luanda, Angola: a molecular epidemiological perspective

2015-06-28Conference object Open access
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dc.contributor.authorPerdigão, João
dc.contributor.authorClemente, Sofia
dc.contributor.authorRamos, Jorge
dc.contributor.authorMasakidi, Pedro
dc.contributor.authorMachado, Diana
dc.contributor.authorSilva, Carla
dc.contributor.authorCouto, Isabel
dc.contributor.authorViveiros, Miguel
dc.contributor.authorTaveira, Nuno
dc.contributor.authorPortugal, Isabel
dc.date.accessioned2016-10-12T13:54:10Z
dc.date.available2016-10-12T13:54:10Z
dc.date.issued2015-06-28
dc.descriptionPoster presented at the 36th Annual Congress of the European Society of Mycobacteriology. Riga, Latvia, 28 June - 1 July 2015pt_PT
dc.description.abstract"Sub-saharan Africa contributes heavily to the tuberculosis (TB) burden worldwide. According to the World Health Organization (WHO), Africa exhibits the highest TB regional incidence rate (280 cases per 100 000 habitants) and the highest Human Immunodeficiency Virus co-infection rate (34%), both of which mostly driven by sub-saharan African countries (4). Yet, to this date, Angola has no surveillance data regarding drug resistance and the latest WHO estimates point to the occurrence of 69 000 new cases in 2013 and an incidence rate of 320 cases per 100 000 habitants in the same period (4). Additionally nothing is known regarding the genetic diversity and population structure of circulating Mycobacterium tuberculosis (M. tuberculosis) strains. Its capital city, Luanda, harbours approximately 33.7% of the country’s population and is responsible for one-third of the TB cases nationwide. In the present study, we have addressed the genetic diversity and drug susceptibility profiles of circulating M. tuberculosis strains recovered from patients followed at a central Luanda hospital unit."pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/15087
dc.language.isoengpt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relationType-II NADH-menaquinone oxidoreductase (NDH-2) and the respiratory chain of M. tuberculosis: new therapeutic targets to fight tuberculosis.
dc.subjectMycobacterium tuberculosispt_PT
dc.subjectDrug resistancept_PT
dc.subjectGenetic diversitypt_PT
dc.subjectAngolapt_PT
dc.titleDrug resistance and genetic diversity of Mycobacterium tuberculosis in Luanda, Angola: a molecular epidemiological perspectivept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardTitleType-II NADH-menaquinone oxidoreductase (NDH-2) and the respiratory chain of M. tuberculosis: new therapeutic targets to fight tuberculosis.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F95406%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73579%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F121859%2F2010/PT
oaire.citation.conferencePlaceRiga, Latviapt_PT
oaire.citation.title36th Annual Congress of the European Society of Mycobacteriologypt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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