Repository logo
 
Publication

Novel synthetic opioids – toxicological aspects and analysis

2019Journal article Open access
Simple item page
dc.contributor.authorTabarra, Inês
dc.contributor.authorSoares, Sofia
dc.contributor.authorRosado, Tiago
dc.contributor.authorGonçalves, Joana
dc.contributor.authorLuís, Ângelo
dc.contributor.authorMalaca, Sara
dc.contributor.authorBarroso, Mário
dc.contributor.authorKeller, Thomas
dc.contributor.authorRestolho, José
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2022-09-26T13:31:08Z
dc.date.available2022-09-26T13:31:08Z
dc.date.issued2019
dc.description.abstractOver the past few years, there has been an emerging number of new psychoactive drugs. These drugs are frequently mentioned as “legal highs”, “herbal highs”, “bath salts” and “research chemicals”. They are mostly sold and advertised on online forums and on the dark web. The emerging new psychoactive substances are designed to mimic the effects of psy- choactive groups, which are often abused drugs. Novel synthetic opioids are a new trend in this context and represent an alarming threat to public health. Given the wide number of fatalities related to these compounds reported within the last few years, it is an important task to accurately identify these compounds in biologic matrices in order to administer an effective treatment and reverse the respiratory depression caused by opioid related substan- ces. Clinicians dealing with fentanyl intoxication cases should consider that it could, in fact, be a fentanyl analogue. For this reason, it is a helpful recommendation to include synthetic opioids in the routine toxicological screening procedures, including analysis in alternative matrices, if available, to investigate poly-drug use and possible tolerance to opioids. To address this public health problem, better international collaboration, effective legislation, effective investigation, control of suspicious “research chemicals” online forums and continu- ous community alertness are required. This article aims to review diverse reported fatalities associated with new synthetic opioids describing them in terms of pharmacology, metabol- ism, posology, available forms, as well as their toxic effects, highlighting the sample proce- dures and analytical techniques available for their detection and quantification in biological matricespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInês Tabarra, Sofia Soares, Tiago Rosado, Joana Gonçalves, Ângelo Luís, Sara Malaca, Mário Barroso, Thomas Keller, José Restolho & Eugenia Gallardo (2019) Novel synthetic opioids – toxicological aspects and analysis, Forensic Sciences Research, 4:2, 111-140pt_PT
dc.identifier.doi10.1080/20961790.2019.1588933pt_PT
dc.identifier.issn2471-1411
dc.identifier.urihttp://hdl.handle.net/10400.26/41847
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francis Grouppt_PT
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectForensic Sciencept_PT
dc.subjectForensic Toxicologypt_PT
dc.subjectNew synthetic opioidspt_PT
dc.subjectBiological Specimenspt_PT
dc.subjectToxicitypt_PT
dc.titleNovel synthetic opioids – toxicological aspects and analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage140pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage111pt_PT
oaire.citation.titleForensic Sciences Researchpt_PT
oaire.citation.volume4pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarroso
person.givenNameMário
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.orcid0000-0001-8848-2734
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication294b555e-48c4-4013-b981-b8917400c56c
relation.isAuthorOfPublication.latestForDiscovery294b555e-48c4-4013-b981-b8917400c56c
relation.isProjectOfPublicationaed55b4c-2c42-4a0d-9beb-c3888de15ae5
relation.isProjectOfPublication.latestForDiscoveryaed55b4c-2c42-4a0d-9beb-c3888de15ae5

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Novel synthetic opioids toxicological aspects and analysis.pdf
Size:
3.18 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

INMLCF - Artigos Científicos