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Placental site trophoblastic tumor: a case report and review of the literature
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Abstract(s)
We present a case of a gravida 1 para 1 woman, who presented with an 11-
month history of amenorrhea after cesarean delivery. The patient was taking
birth control pills at the time of presentation. She was observed with a slight
elevation of serum β-hCG level, an enlarged heterogeneous uterus and
hematometra. A biopsy was performed, and the patient was diagnosed with
placental site trophoblastic tumor; the patient then underwent surgery.
Placental site trophoblastic tumor is the rarest form of gestational
trophoblastic disease, derived from intermediate trophoblast cells. It does not
have a pathognomonic appearance; therefore, correlation with medical
history, as well as results of laboratory tests and pathological analysis is
mandatory. It is a relatively chemoresistant tumor, posing considerable
therapeutic challenges; patients with localized disease are managed with
surgery and those with metastatic disease require additional chemotherapy.
Herein, we review the main features of this entity and top differential
diagnosis, as the rarity of this tumor is associated with imaging and
pathological pitfalls, reinforcing the need for further experience in this field.
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Citation
Rita Lucas; Teresa Margarida Cunha; Filipa Batista Santos. Placental Site Trophoblastic Tumor: a Case Report and Review of the Literature, Journal of Radiology Case Reports, 9, 4, 14-22, 2015.