Hyperpigmentation associated with hormonal contraceptive use

Peixoto, R.; Fonseca, A.P.

Publication

Hyperpigmentation associated with hormonal contraceptive use

2019-03Journal article

dc.contributor.author	Peixoto, R.
dc.contributor.author	Fonseca, A.P.
dc.date.accessioned	2020-05-24T14:11:00Z
dc.date.available	2020-05-24T14:11:00Z
dc.date.issued	2019-03
dc.description.abstract	Introduction: Melanocytes are cells which are present in the human skin and they are responsible for the melanin production. They can be found in the basal stratum of the epidermis and they have some prolongations extending until the stratum corneum. Melanin synthesis may increase in the presence of some factors and some irregular brownish spots – hyperpigmentations – may appear. Factors which can trigger melanogenesis are excessive sun exposure, hormonal contraception, hormonal reposition therapy, pregnancy, medicines, cosmetics, stress or genetics. Aim: Understanding of the relationship between hormonal contraceptives and hyperpigmentation. Material and Methods: A bibliographic review through a research in diverse databases (PubMed, Google Scholar, ScienceDirect and Wiley Online Library). Results/Discussion: According to some authors, estrogenic components found in hormonal contraceptives are associated with hyperpigmentation situations. In the case of progestagenic components, opinions diverge: some studies substantiate that progesterone has the ability to increase melanogenesis and others that it may have the opposite effect of estrogen. In a general way, most researchers say that hormonal contraceptives affect melanin synthesis; however others reject that fact. Conclusion: It is verified the relationship between hormonal contraceptives and hyperpigmentation. However, this topic is not sufficiently well approached, so future investigations are needed to allow its best understanding.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.doi	DOI- 10.5281/zenodo.2616927	pt_PT
dc.identifier.issn	2394-9414
dc.identifier.uri	http://hdl.handle.net/10400.26/32346
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Thomson Reuters	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	pt_PT
dc.subject	Hormonal contraceptives	pt_PT
dc.subject	Hyperpigmentation	pt_PT
dc.subject	Estrogen	pt_PT
dc.subject	Progesterone	pt_PT
dc.subject	Anticoncepcionais hormonais	pt_PT
dc.subject	Hiperpigmentação	pt_PT
dc.subject	Estrogénio	pt_PT
dc.subject	Progesterona	pt_PT
dc.title	Hyperpigmentation associated with hormonal contraceptive use	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	20	pt_PT
oaire.citation.issue	3	pt_PT
oaire.citation.startPage	12	pt_PT
oaire.citation.volume	6	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT