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Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval

2016-02-04Journal article Open access
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dc.contributor.authorCastro, André Lobo
dc.contributor.authorTarelho, Sónia
dc.contributor.authorDias, Mário
dc.contributor.authorReis, Flávio
dc.contributor.authorTeixeira, Helena M.
dc.date.accessioned2023-02-28T16:42:47Z
dc.date.available2023-02-28T16:42:47Z
dc.date.issued2016-02-04
dc.description.abstractGamma-hydroxybutyric acid (GHB) is an endogenous compound which has a story of clinical use and illicit abuse since the 1960’s. The possibility to use a multi-sample approach of GHB evaluation, including whole blood and hair, to better characterize a forensic toxicology case and evaluate a possible causal association with the death, is an exciting up-to-date issue. In addition, its post-mortem behaviour, namely regarding degradation and metabolism, has been increasingly investigated as a putative biomarker for post-mortem interval (PMI) estimation. Thus, In order to contribute to clarify this specific aspect, whole blood and hair post-mortem GHB levels were evaluated in thirty two real cases with previous information on death and autopsy data. The results obtained suggest that the PMI (until 5 days between death and sampling) influences GHB whole blood concentration, but not GHB levels in hair samples. No differences were encountered for the other parameters evaluated, including age, gender, cause of death and presence or absence of substances. This study brings new insights regarding the usefulness of GHB levels in forensic toxicology, which might be further strengthened with larger, but comparable, studies from other laboratories and institutions in the context of legal medicine.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationCastro, A.L., Tarelho, S., Dias, M. et al. Comparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem interval. Int J Legal Med 130, 959–965 (2016).pt_PT
dc.identifier.doi10.1007/s00414-016-1321-8pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/43980
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Linkpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00414-016-1321-8pt_PT
dc.subjectGamma-hydroxybutyric acid (GHB)pt_PT
dc.subjectPost-mortem intervalpt_PT
dc.subjectEndogenous valuespt_PT
dc.subjectHair and whole blood samplespt_PT
dc.titleComparison of endogenous GHB concentrations in blood and hair in death cases with emphasis on the post mortem intervalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage965pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage959pt_PT
oaire.citation.titleInternational Journal of Legal Medicinept_PT
oaire.citation.volume130pt_PT
person.familyNameLobo Castro
person.familyNameTarelho
person.familyNameDias
person.familyNameFernandes Reis
person.familyNameTeixeira
person.givenNameAndré
person.givenNameSónia
person.givenNameMário
person.givenNameFlávio Nelson
person.givenNameHelena M.
person.identifier.ciencia-id1C1D-1326-C311
person.identifier.ciencia-id4214-85EB-E58C
person.identifier.orcid0000-0002-7258-8523
person.identifier.orcid0000-0001-8366-6702
person.identifier.orcid0000-0002-5900-5899
person.identifier.orcid0000-0003-3401-9554
person.identifier.orcid0000-0001-7570-5521
person.identifier.scopus-author-id26221673200
person.identifier.scopus-author-id7003981256
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfedcfeb0-e610-4375-aa1e-5ac1fa74cd28
relation.isAuthorOfPublication631cbcb7-4c75-4fc1-b4cf-8445d428f1de
relation.isAuthorOfPublicationb24227f2-a261-4e33-ab53-3edf34744335
relation.isAuthorOfPublication6e1a3bac-2106-4a1a-81a8-c996f61a3d0e
relation.isAuthorOfPublication04b8f471-69fa-4cc1-942a-7bc7e690a0d4
relation.isAuthorOfPublication.latestForDiscoveryb24227f2-a261-4e33-ab53-3edf34744335

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