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Artemia salina model: An important tool to screen general toxicity samples

2020Journal article Open access
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dc.contributor.authorNtungwe, Epole
dc.contributor.authorIsca, Vera M. S.
dc.contributor.authorPereira, Paula
dc.contributor.authorCebola, Maria-João
dc.contributor.authorRijo, Patricia
dc.date.accessioned2025-05-13T13:39:44Z
dc.date.available2025-05-13T13:39:44Z
dc.date.issued2020
dc.description.abstractMedicinal plants are a good source of novel therapeutic drugs, due to the phytochemicals present. Artemia, commonly known as brine shrimp, is a tiny halophilic invertebrate belonging to class Crustacean, which plays an important role in saline aquatic and marine eco-systems. Besides its usage in aquaculture, it is also highly valued for its application in toxicity detection and it is used in areas such as Ecology, Physiology, Ecotoxicology, Aquaculture and Genetics. Furthermore, Artemia based lethality assay (brine shrimp lethality assay, BSLA) is rapid, convenient and low cost. Presently, brine shrimp lethality assays are enormously employed in research and applied toxicology. It has been used in the study of natural products as a preliminary toxicity assay to screen a large number of extracts and compounds for drug discovery in medicinal plants. The aim of this review paper is to collect, organize, select and discuss the existing knowledge about the different uses of Artemia salina as a bench-top bioassay for the discovery and purification of bioactive natural products.eng
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNtungwe N, E., Domínguez-Martín, E. M., Roberto, A., Tavares, J., Isca, V., Pereira, P., ... & Rijo, P. (2020). Artemia species: An important tool to screen general toxicity samples. Current Pharmaceutical Design, 26(24), 2892-2908
dc.identifier.doi10.2174/1381612826666200406083035
dc.identifier.issn1873-4286
dc.identifier.urihttp://hdl.handle.net/10400.26/57804
dc.language.isoengpt_PT
dc.peerreviewedyes
dc.publisherEurekaselectpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectArtemia
dc.subjectbrine shrimp
dc.subjectgeneral toxicity
dc.subjectnatural products
dc.subjectcorrelation
dc.subjectalternative model
dc.subjectscreening
dc.titleArtemia salina model: An important tool to screen general toxicity samplespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2908pt_PT
oaire.citation.issue24pt_PT
oaire.citation.startPage2892pt_PT
oaire.citation.titleCurrent Pharmaceutical Designpt_PT
oaire.citation.volume26pt_PT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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