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Activity patterns of serotonin neurons underlying cognitive flexibility

dc.contributor.authorMatias, Sara
dc.contributor.authorLottem, Eran
dc.contributor.authorDugué, Guillaume P
dc.contributor.authorMainen, Zachary F
dc.date.accessioned2018-06-29T14:42:12Z
dc.date.available2018-06-29T14:42:12Z
dc.date.issued2017-03-21
dc.description.abstractSerotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to study a population of dorsal raphe serotonin neurons, whose activity we could link to normal reversal learning using pharmacogenetics. We found that these neurons are activated by both positive and negative prediction errors, and thus report signals similar to those proposed to promote learning in conditions of uncertainty. Furthermore, by comparing the cue responses of serotonin and dopamine neurons, we found differences in learning rates that could explain the importance of serotonin in inhibiting perseverative responding. Our findings show how the activity patterns of serotonin neurons support a role in cognitive flexibility, and suggest a revised model of dopamine-serotonin opponency with potential clinical implications.pt_PT
dc.description.sponsorshipERC 250334, 5-HT Optogenetic
dc.description.sponsorshipERC 671251, 5-HT Circuits
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.7554/eLife.20552pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/23190
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publishereLife Sciences Publicationspt_PT
dc.relationTESTING THE ROLE OF SEROTONIN IN SENSORY GATING: AN OPTOGENETIC APPROACH
dc.subjectDorsal Raphe Nucleuspt_PT
dc.subjectMicept_PT
dc.subjectSerotonergic Neuronspt_PT
dc.subjectReversal Learningpt_PT
dc.titleActivity patterns of serotonin neurons underlying cognitive flexibilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTESTING THE ROLE OF SEROTONIN IN SENSORY GATING: AN OPTOGENETIC APPROACH
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F43072%2F2008/PT
oaire.citation.volume6pt_PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationbfd00388-aff3-49fd-977b-9d57a6237f21
relation.isProjectOfPublication.latestForDiscoverybfd00388-aff3-49fd-977b-9d57a6237f21

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