A rare cause of agranulocytosis

Luís, Helena; Barros, Carolina; Fernandes, Mauro; Granito, Sofia

http://hdl.handle.net/10400.26/37858

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Authors

Luís, Helena

Barros, Carolina

Fernandes, Mauro

Granito, Sofia

Abstract(s)

Clozapine, an atypical antipsychotic agent, is useful in the treatment of patients with psychotic symptoms. However, severe adverse effects, such as agranulocytosis, can restrict its indications. We present a case of a 42-year-old Caucasian woman with a 4-year history of persistent delusion disorder, who presented with fatigue and fever and was ultimately diagnosed with agranulocytosis due to clozapine. Clozapine-induced granulocytosis is an uncommon condition, but potentially fatal in consequences. Each patient with an episode of agranulocytosis should be assessed individually, with special attention to risk factors. Upon that, the decision about clozapine rechallenge or withdrawal should be made