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Crescent-like lesions as an early signature of nephropathy in a rat model of prediabetes induced by a hypercaloric diet

2020-03-25Journal article Open access
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dc.contributor.authorNunes, Sara
dc.contributor.authorAlves, André
dc.contributor.authorPreguiça, Inês
dc.contributor.authorBarbosa, Adelaide
dc.contributor.authorVieira, Pedro
dc.contributor.authorMendes, Fernando
dc.contributor.authorMartins, Diana
dc.contributor.authorViana, Sofia
dc.contributor.authorReis, Flávio
dc.date.accessioned2021-04-27T22:22:27Z
dc.date.available2021-04-27T22:22:27Z
dc.date.issued2020-03-25
dc.description.abstractDiabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly inefficient. This ambition greatly depends on the existence of accurate early biomarkers and novel molecular targets, which only may arise with a more thorough knowledge of disease pathophysiology. We used a rat model of prediabetes induced by 23 weeks of high-sugar/high-fat (HSuHF) diet to characterize the phenotype of early renal dysfunction and injury. When compared with the control animals, HSuHF-treated rats displayed a metabolic phenotype compatible with obese prediabetes, displaying impaired glucose tolerance and insulin sensitivity, along with hypertriglyceridemia, and lipid peroxidation. Despite unchanged creatinine levels, the prediabetic animals presented glomerular crescent-like lesions, accompanied by increased kidney Oil-Red-O staining, triglycerides content and mRNA expression of IL-6 and iNOS. This model of HSuHF-induced prediabetes can be a useful tool to study early features of DN, namely crescent-like lesions, an early signature that deserves in-depth elucidation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nu12040881pt_PT
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.26/36314
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCNC. IBILI
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCNC. IBILI
dc.relationCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBody Weightpt_PT
dc.subjectCollagen Type IVpt_PT
dc.subjectDiabetic Nephropathiespt_PT
dc.subjectDiet, Diabeticpt_PT
dc.subjectDisease Models, Animalpt_PT
dc.subjectEnergy Intakept_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectKidney Function Testspt_PT
dc.subjectKidney Glomeruluspt_PT
dc.subjectLipid Metabolismpt_PT
dc.subjectMalept_PT
dc.subjectPrediabetic Statept_PT
dc.subjectRatspt_PT
dc.titleCrescent-like lesions as an early signature of nephropathy in a rat model of prediabetes induced by a hypercaloric dietpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCNC. IBILI
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCNC. IBILI
oaire.awardTitleCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-NUT%2F31712%2F2017/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04539%2F2020/PT
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oaire.citation.issue4pt_PT
oaire.citation.startPage881pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume12pt_PT
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oaire.fundingStream6817 - DCRRNI ID
person.familyNameRamalho Pereira Nunes
person.familyNameAlves
person.familyNameMendes Preguiça
person.familyNameMendes
person.familyNameMartins
person.familyNameViana
person.familyNameFernandes Reis
person.givenNameSara Raquel
person.givenNameAndré
person.givenNameInês
person.givenNameFernando
person.givenNameDiana
person.givenNameSofia
person.givenNameFlávio Nelson
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person.identifier.orcid0000-0002-0240-9059
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person.identifier.orcid0000-0002-5205-8939
person.identifier.orcid0000-0002-1457-8992
person.identifier.orcid0000-0002-1316-1319
person.identifier.orcid0000-0003-3401-9554
person.identifier.scopus-author-id36574173900
person.identifier.scopus-author-id55353634200
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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