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Fetal-maternal interface impedance parallels local NADPH oxidase related superoxide production.

dc.contributor.authorGuedes-Martins, L
dc.contributor.authorSilva, E
dc.contributor.authorGaio, AR
dc.contributor.authorSaraiva, J
dc.contributor.authorSoares, AI
dc.contributor.authorAfonso, J
dc.contributor.authorMacedo, F
dc.contributor.authorAlmeida, H
dc.date.accessioned2015-06-28T16:28:13Z
dc.date.available2015-06-28T16:28:13Z
dc.date.issued2015
dc.description.abstractBlood flow assessment employing Doppler techniques is a useful procedure in pregnancy evaluation, as it may predict pregnancy disorders coursing with increased uterine vascular impedance, as pre-eclampsia. While the local causes are unknown, emphasis has been put on reactive oxygen species (ROS) excessive production. As NADPH oxidase (NOX) is a ROS generator, it is hypothesized that combining Doppler assessment with NOX activity might provide useful knowledge on placental bed disorders underlying mechanisms. A prospective longitudinal study was performed in 19 normal course, singleton pregnancies. Fetal aortic isthmus (AoI) and maternal uterine arteries (UtA) pulsatility index (PI) were recorded at two time points: 20-22 and 40-41 weeks, just before elective Cesarean section. In addition, placenta and placental bed biopsies were performed immediately after fetal extraction. NOX activity was evaluated using a dihydroethidium-based fluorescence method and associations to PI values were studied with Spearman correlations. A clustering of pregnancies coursing with higher and lower PI values was shown, which correlated strongly with placental bed NOX activity, but less consistently with placental tissue. The study provides evidence favoring that placental bed NOX activity parallels UtA PI enhancement and suggests that an excess in oxidation underlies the development of pregnancy disorders coursing with enhanced UtA impedance.por
dc.identifier.citationRedox Biol. 2015 Apr 20;5:114-123.por
dc.identifier.doi10.1016/j.redox.2015.04.007
dc.identifier.urihttp://hdl.handle.net/10400.26/9079
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationAGE-DEPENDENT ALTERATIONS IN REDOX BALANCE: ROLE IN FEMALE REPRODUCTION
dc.subjectNADPH Oxidasepor
dc.subjectNADH, NADPH Oxidoreductasespor
dc.subjectPregnancypor
dc.subjectNADH, NADPH Oxidorreductasespor
dc.subjectNADPH Oxidasepor
dc.subjectGravidezpor
dc.titleFetal-maternal interface impedance parallels local NADPH oxidase related superoxide production.por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAGE-DEPENDENT ALTERATIONS IN REDOX BALANCE: ROLE IN FEMALE REPRODUCTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72536%2F2010/PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublicationa96c2509-d4e0-4840-8ca5-6c1df9eaec00
relation.isProjectOfPublication.latestForDiscoverya96c2509-d4e0-4840-8ca5-6c1df9eaec00

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