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Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epidemiological study

2021Journal article Open access
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dc.contributor.authorSantos, E
dc.contributor.authorRocha, AL
dc.contributor.authorOliveira, V
dc.contributor.authorFerro, D
dc.contributor.authorSamões, R
dc.contributor.authorSousa, AP
dc.contributor.authorFigueiroa, S
dc.contributor.authorMendonça, T
dc.contributor.authorAbreu, P
dc.contributor.authorGuimarães, J
dc.contributor.authorSousa, R
dc.contributor.authorMelo, C
dc.contributor.authorCorreia, I
dc.contributor.authorDurães, J
dc.contributor.authorSousa, L
dc.contributor.authorFerreira, J
dc.contributor.authorde Sá, J
dc.contributor.authorSousa, F
dc.contributor.authorSequeira, M
dc.contributor.authorCorreia, AS
dc.contributor.authorAndré, AL
dc.contributor.authorBasílio, C
dc.contributor.authorArenga, M
dc.contributor.authorMendes, I
dc.contributor.authorMarques, IB
dc.contributor.authorPerdigão, S
dc.contributor.authorFelgueiras, H
dc.contributor.authorAlves, I
dc.contributor.authorCorreia, F
dc.contributor.authorBarroso, C
dc.contributor.authorMorganho, A
dc.contributor.authorCarmona, C
dc.contributor.authorPalavra, F
dc.contributor.authorSantos, M
dc.contributor.authorSalgado, V
dc.contributor.authorPalos, A
dc.contributor.authorNzwalo, H
dc.contributor.authorTimóteo, A
dc.contributor.authorGuerreiro, R
dc.contributor.authorIsidoro, L
dc.contributor.authorBoleixa, D
dc.contributor.authorCarneiro, P
dc.contributor.authorNeves, E
dc.contributor.authorSilva, AM
dc.contributor.authorGonçalves, G
dc.contributor.authorLeite, MI
dc.contributor.authorSá, MJ
dc.date.accessioned2021-09-27T20:54:31Z
dc.date.available2021-09-27T20:54:31Z
dc.date.issued2021
dc.description.abstractIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients were included. Results: A total of 180 patients met the 2015 Wingerchuk NMOSD criteria, 77 were AQP4-antibody positive (Abs+), 67 MOG-Abs+, and 36 seronegative. Point prevalence on December 31, 2018 was 1.71/100,000 for NMOSD, 0.71/100,000 for AQP4-Abs+, 0.65/100,000 for MOG-Abs+, and 0.35/100,000 for seronegative NMOSD. A total of 44 new NMOSD cases were identified during the two-year study period (11 AQP4-Abs+, 27 MOG-Abs+, and 6 seronegative). The annual incidence rate in that period was 0.21/100,000 person-years for NMOSD, 0.05/100,000 for AQP4-Abs+, 0.13/100,000 for MOG-Abs+, and 0.03/100,000 for seronegative NMOSD. AQP4-Abs+ predominated in females and was associated with autoimmune disorders. Frequently presented with myelitis. Area postrema syndrome was exclusive of this subtype, and associated with higher morbidity/mortality than other forms of NMOSD. MOG-Ab+ more often presented with optic neuritis, required less immunosuppression, and had better outcome. Conclusion: Epidemiological/clinical NMOSD profiles in the Portuguese population are similar to other European countriespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMult Scler Relat Disord. 2021;56: 103258pt_PT
dc.identifier.doi10.1016/j.msard.2021.103258pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/37588
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectNeuromielite Óptica/diagnósticopt_PT
dc.subjectNeuromielite Óptica/epidemiologypt_PT
dc.subjectNeuromyelitis Optica /diagnosispt_PT
dc.subjectNeuromyelitis Optica/epidemiologypt_PT
dc.titleNeuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epidemiological studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage103258pt_PT
oaire.citation.titleMultiple Sclerosis and Related Disorderspt_PT
oaire.citation.volume56pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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