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Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

2023Journal article Open access
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dc.contributor.authorFevereiro-Martins, M
dc.contributor.authorSantos, AC
dc.contributor.authorMarques-Neves, C
dc.contributor.authorGuimarães, H
dc.contributor.authorBicho, M
dc.contributor.authorAfonso, C
dc.contributor.authorFerreira, J
dc.contributor.authorEspírito Santo, R
dc.contributor.authorTeixeira, F
dc.contributor.authorRosa, R
dc.contributor.authorCarneiro, CV
dc.contributor.authorFerreira, M
dc.contributor.authorMatos, T
dc.contributor.authorNeiva, L
dc.contributor.authorPereira, S
dc.contributor.authorAires, S
dc.contributor.authorParreira, R
dc.contributor.authorMelnik, Z
dc.contributor.authorFaria, J
dc.contributor.authorTeixeira, J
dc.contributor.authorBarros, P
dc.contributor.authorAlmeida, J
dc.contributor.authorMalheiro, B
dc.contributor.authorRodrigues, PC
dc.contributor.authorAlbuquerque, L
dc.contributor.authorFreitas, A
dc.contributor.authorBarros, P
dc.contributor.authorKotchekova, N
dc.contributor.authorFreitas, R
dc.contributor.authorSilveira, AC
dc.contributor.authorFerreira, A
dc.contributor.authorMorais, B
dc.contributor.authorTeixeira, S
dc.contributor.authorMota, M
dc.contributor.authorGuerra, M
dc.contributor.authorCoimbra, L
dc.contributor.authorGigante, J
dc.contributor.authorFerreira, M
dc.contributor.authorLapa, P
dc.contributor.authorMonteiro, M
dc.contributor.authorAlfaiate, M
dc.contributor.authorRodrigues, T
dc.contributor.authorPina, T
dc.contributor.authorRosário, M
dc.contributor.authorSilva, R
dc.contributor.authorBreda, J
dc.contributor.authorBazenga, F
dc.contributor.authorPinto, JA
dc.date.accessioned2023-05-08T22:05:01Z
dc.date.available2023-05-08T22:05:01Z
dc.date.issued2023
dc.description.abstractPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraefes Arch Clin Exp Ophthalmol . 2023 May 2. doi: 10.1007/s00417-023-06072-7.pt_PT
dc.identifier.doi10.1007/s00417-023-06072-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/44740
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectRetinopatia da Prematuridadept_PT
dc.subjectRecém-Nascido Prematuropt_PT
dc.subjectBiomarcadorespt_PT
dc.subjectRetinopathy of Prematuritypt_PT
dc.subjectInfant, Prematurept_PT
dc.subjectBiomarkerspt_PT
dc.titleComplete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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