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Usefulness of the Hepatocyte Growth Factor as a Predictor of Mortality in Patients Hospitalized With Acute Heart Failure Regardless of Ejection Fraction

2016-08-15Journal article Open access
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dc.contributor.authorPérez-Calvo, JI
dc.contributor.authorMorales-Rull, JL
dc.contributor.authorGimeno-Orna, JA
dc.contributor.authorLasierra-Díaz, P
dc.contributor.authorJosa-Laorden, C
dc.contributor.authorPuente-Lanzarote, JJ
dc.contributor.authorBettencourt, P
dc.contributor.authorPascual-Figal, DA
dc.date.accessioned2016-08-11T21:26:46Z
dc.date.available2016-08-11T21:26:46Z
dc.date.issued2016-08-15
dc.description.abstractHepatocyte growth factor (HGF) plays a role in the improvement of cardiac function and remodeling. Their serum levels are strongly related with mortality in chronic systolic heart failure (HF). The aim of this study was to study prognostic value of HGF in acute HF, interaction with ejection fraction, renal function, and natriuretic peptides. We included 373 patients (age 76 ± 10 years, left ventricular ejection fraction [LVEF] 46 ± 14%, 48% men) consecutively admitted for acute HF. Blood samples were obtained at admission. All patients were followed up until death or close of study (>1 year, median 371 days). HGF concentrations were determined using a commercial enzyme-linked immunosorbent assay (human HGF immunoassay). The predictive power of HGF was estimated by Cox regression with calculation of Harrell C-statistic. HGF had a median of 1,942 pg/ml (interquartile rank 1,354). According to HGF quartiles, mortality rates (per 1,000 patients/year) were 98, 183, 375, and 393, respectively (p <0.001). In Cox regression analysis, HGF (hazard ratio1SD = 1.5, 95% confidence interval 1.1 to 2.1, p = 0.002) and N-terminal pro b-type natriuretic peptide (NT-proBNP; hazard ratio1SD = 1.8, 95% confidence interval 1.2 to 2.6, p = 0.002) were independent predictors of mortality. Interaction between HGF and LVEF, origin, and renal function was nonsignificant. The addition of HGF improved the predictive ability of the models (C-statistic 0.768 vs 0.741, p = 0.016). HGF showed a complementary value over NT-proBNP (p = 0.001): mortality rate was 490 with both above the median versus 72 with both below. In conclusion, in patients with acute HF, serum HGF concentrations are elevated and identify patients at higher risk of mortality, regardless of LVEF, ischemic origin, or renal function. HGF had independent and additive information over NT-proBNP.pt_PT
dc.identifier.citationAm J Cardiol. 2016 Aug 15;118(4):543-9.pt_PT
dc.identifier.doi10.1016/j.amjcard.2016.05.048pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/14442
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectFalência Hepática Agudapt_PT
dc.subjectFactor de Crescimento de Hepatócitopt_PT
dc.subjectMortalidade Hospitalarpt_PT
dc.subjectLiver Failure, Acutept_PT
dc.subjectHospital Mortalitypt_PT
dc.subjectHepatocyte Growth Factorpt_PT
dc.titleUsefulness of the Hepatocyte Growth Factor as a Predictor of Mortality in Patients Hospitalized With Acute Heart Failure Regardless of Ejection Fractionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage549pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage543-9pt_PT
oaire.citation.volume118pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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