Publication
Neuroversion: a possible mechanism of action of ECT in acute mania
| dc.contributor.author | Silva-dos-Santos, Amílcar | |
| dc.contributor.author | Venda, Diana | |
| dc.contributor.author | Sales, Miguel | |
| dc.date.accessioned | 2023-06-08T20:22:00Z | |
| dc.date.available | 2023-06-08T20:22:00Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | The first-line treatments for acute mania are lithium, antiepileptic moodstabilizers, and antipsychotic drugs. Electroconvulsive therapy (ECT) is reserved for drug-resistant patients, although it is the first-line treatment for severe or delirious mania with life-threatening physical exhaustion. Contrary to depression, there is a paucity of evidence for the use of ECT in acute mania. However, available literature indicates that ECT seems effective in treating acute mania, with response rates between 80% and 90%, even in drug-resistant patients. Yet, its electrophysiological and molecular pathways remain unknown. We present the curious case of a 63-year-old woman, followed at our psychiatric outpatient clinic for bipolar disorder type I, admitted to our inpatient unit in a manic state with psychotic features. Due to bradycardia episodes secondary to the psychiatric medication, she was submitted to ECT. After a single session, her symptoms improved, despite no evoked seizures. We compare this curious phenomenon to the well-known procedure of cardioversion and name it neuroversion e in other words, a possible normalization of brain activity and behavior triggered by a unique session of electrical stimulation. However, we acknowledge that further research, including randomized clinical trials, are needed to study this reported event. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.brs.2021.10.094 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/45128 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Neuroversion | pt_PT |
| dc.subject | Electroconvulsive therapy | pt_PT |
| dc.subject | Mania | pt_PT |
| dc.subject | Bipolar Disorder | pt_PT |
| dc.title | Neuroversion: a possible mechanism of action of ECT in acute mania | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | 4th International Brain Stimulation Meeting, Charleston, SC USA | pt_PT |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 1617 | pt_PT |
| oaire.citation.title | Brain Stimulation | pt_PT |
| oaire.citation.volume | 14 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |