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Lower prevalence of congenital cytomegalovirus infection in Portugal: possible impact of COVID-19 lockdown?

2021Journal article Open access
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dc.contributor.authorFernandez, C
dc.contributor.authorChasqueira, MJ
dc.contributor.authorMarques, A
dc.contributor.authorRodrigues, L
dc.contributor.authorMarçal, M
dc.contributor.authorTuna, M
dc.contributor.authorBraz, MC
dc.contributor.authorNeto, AS
dc.contributor.authorMendes, C
dc.contributor.authorLito, D
dc.contributor.authorRocha, P
dc.contributor.authorVasconcellos, G
dc.contributor.authorMenezes, MF
dc.contributor.authorSousa, MJ
dc.contributor.authorNunes, C
dc.contributor.authorPaixão, P
dc.date.accessioned2021-10-12T21:33:46Z
dc.date.available2021-10-12T21:33:46Z
dc.date.issued2021
dc.description.abstractCytomegalovirus (CMV) is the most frequent cause of congenital infection all over the world. Its prevalence ranges from 0.2 to 2.2%. Transmission from children to their pregnant mothers is a well-known risk factor, particularly if they attend a childcare centre. This study aims to compare the prevalence of CMV congenital infection (CMV_CI) in Portugal (Lisbon) between two studies, performed respectively in 2019 and 2020. In the 2019 study, performed in two hospitals, we found a 0.67% CMV_CI prevalence, using a pool strategy previously tested with saliva samples. In the 2020 study, using the same pool approach in four hospitals (the previous and two additional), and based on 1277 samples, the prevalence was 0.078%.Conclusion: The close temporal coincidence with COVID-19 lockdown suggests that these measures may have had a significant impact on this reduction, although other explanations cannot be ruled-out. What is Known: • Cytomegalovirus is the leading cause of congenital infection. • Behavioural measures decrease cytomegalovirus seroconversion in pregnant women. What is New: • From 2019 to 2020 there was a significant reduction in the prevalence of congenital CMV infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Pediatr . 2021 Sep 30;1-4.pt_PT
dc.identifier.doi10.1007/s00431-021-04271-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/37678
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCriançapt_PT
dc.subjectCOVID-19pt_PT
dc.subjectInfecções por Citomegalovíruspt_PT
dc.subjectChildpt_PT
dc.subjectCytomegalovirus Infectionspt_PT
dc.titleLower prevalence of congenital cytomegalovirus infection in Portugal: possible impact of COVID-19 lockdown?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuropean Journal of Pediatricspt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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