Repository logo
 
Publication

Follicular Fluid redox involvement for ovarian follicle growth

dc.contributor.authorFreitas, C
dc.contributor.authorNeto, AC
dc.contributor.authorMatos, L
dc.contributor.authorSilva, E
dc.contributor.authorRibeiro, Â
dc.contributor.authorSilva-Carvalho, JL
dc.contributor.authorAlmeida, Henrique
dc.date.accessioned2017-08-24T20:23:26Z
dc.date.available2017-08-24T20:23:26Z
dc.date.issued2017-07-12
dc.description.abstractAs the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a reservoir rich in biomolecules. In some aspects, it is similar to the plasma, but it also exhibits differences that likely relate to its specific localization around the oocyte. The chemical composition indicates that the follicular fluid is able to detect and buffer excessive amounts of reactive oxygen species, employing a variety of antioxidants, some of them components of the intracellular milieu.An important part is played by albumin through specific cysteine residues. But the fluid contains other molecules whose cysteine residues may be involved in sensing and buffering the local oxidative conditions. How these molecules are recruited and regulated to intervene such process is unknown but it is a critical issue in reproduction.In fact, important proteins in the FF, that regulate follicle growth and oocyte quality, exhibit cysteine residues at specific points, whose untoward oxidation would result in functional loss. Therefore, preservation of controlled oxidative conditions in the FF is a requirement for the fine-tuned oocyte maturation process. In contrast, its disturbance enhances the susceptibility to the establishment of reproductive disorders that would require the intervention of reproductive medicine technology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Ovarian Res. 2017 Jul 12;10(1):44. dpt_PT
dc.identifier.doi10.1186/s13048-017-0342-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/18863
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectFolículo Ováricopt_PT
dc.subjectLíquido Folicularpt_PT
dc.titleFollicular Fluid redox involvement for ovarian follicle growthpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage44pt_PT
oaire.citation.volume10pt_PT
person.familyNameAlmeida
person.givenNameHenrique
person.identifier1471623
person.identifier.ciencia-id0D19-14A5-3B1B
person.identifier.orcid0000-0002-3036-3211
person.identifier.scopus-author-id23017711100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1abde5dc-dd10-473e-8538-457ee82935d7
relation.isAuthorOfPublication.latestForDiscovery1abde5dc-dd10-473e-8538-457ee82935d7

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Follicular Fluid redox involvement.pdf
Size:
738.91 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description: