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Evaluation of an in-house molecular HIV-1 test to assess mother-to-child HIV-1 transmission in Angola (the APEHC cohort)

2015-09-27Conference object Open access
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dc.contributor.authorMartin, F.
dc.contributor.authorPalladino, C.
dc.contributor.authorMateus, R.
dc.contributor.authorClemente, S.
dc.contributor.authorGomes, P.
dc.contributor.authorTaveira, N.
dc.date.accessioned2016-10-12T14:27:42Z
dc.date.available2016-10-12T14:27:42Z
dc.date.issued2015-09-27
dc.descriptionPoster presented at the 17th Annual International Meeting of the Institute of Human Virology. Baltimore, 27-30 September 2015pt_PT
dc.description.abstract"Mother-to-child-transmission (MTCT) rate has decreased sharply in recent years in most of the sub-Saharan Africa, however 220,000 children acquired HIV-1 in 2014. PCR detection of proviral DNA is the most sensitive method for early infant diagnosis (EID) of HIV-1 infection. Commercial kits are available but they have poor sensitivity with divergent non-B subtypes and high costs (≈30€ per test) which limit their use in resource-limited settings. The HIV-1 epidemic in Angola is driven by highly divergent strains of all group M subtypes, except B, as well as multiple recombinant forms (CRFs and URFs) making EID a challenge in this setting. The aim of this study was to develop and validate a qualitative, inexpensive and sensitive “inhouse” HIV-1 EID assay on heel prick dried blood spots (DBS) from infants of the Hospital da Divina Providência (HDP) in Luanda, Angola and determine the current HIV-1 MTCT rate in the Angolan PErinatal HIV Cohort (APEHC)."pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia - Portugal ; European Unionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/15090
dc.language.isoengpt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.subjectMolecular HIV-1 testpt_PT
dc.subjectIn-housept_PT
dc.subjectMother-to-child HIV-1 transmissionpt_PT
dc.subjectAngolapt_PT
dc.titleEvaluation of an in-house molecular HIV-1 test to assess mother-to-child HIV-1 transmission in Angola (the APEHC cohort)pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/VIH%2FSAU%2F0029%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FAR%2F115290%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F87488%2F2012/PT
oaire.citation.conferencePlaceBaltimorept_PT
oaire.citation.title17th Annual International Meeting of the Institute of Human Virologypt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationc3b60260-41c1-4212-93cd-191d5b2e6133
relation.isProjectOfPublicatione63cde82-fa32-4aed-90e7-c9443427f2e1
relation.isProjectOfPublication15aded3d-70a1-4e02-8508-f5e6a4e56f9a
relation.isProjectOfPublicationa39e07a2-cbb9-4cf3-9fc2-354373f654f8
relation.isProjectOfPublication.latestForDiscoveryc3b60260-41c1-4212-93cd-191d5b2e6133

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