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Transitions Between Preexposure Prophylaxis Eligibility States and HIV Infection in The Lisbon Cohort of HIV-Negative Men Who Have Sex with Men: a Multistate Model Analysis

2021-10-27Journal article Open access
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dc.contributor.authorMeireles, Paula
dc.contributor.authorRocha, Miguel
dc.contributor.authorMoreira, Carla
dc.contributor.authorPlankey, Michael
dc.contributor.authorBarros, Henrique
dc.date.accessioned2024-06-11T14:44:37Z
dc.date.available2024-06-11T14:44:37Z
dc.date.issued2021-10-27
dc.date.updated2024-06-10T12:43:46Z
dc.description.abstractWe aimed to describe transitions between preexposure prophylaxis (PrEP) eligibility and human immunodeficiency virus (HIV) infection among HIV-negative men who have sex with men (MSM). We used data from 1,885 MSM, who had not used PrEP, enrolled in the Lisbon Cohort of MSM, with at least 2 consecutive measurements of PrEP eligibility from 2014-2020. A time-homogeneous Markov multistate model was applied to describe the transitions between states of PrEP eligibility-eligible and ineligible-and from these to HIV infection (HIV). The intensities of the transitions were closer for ineligible-to-eligible and eligible-to-ineligible transitions (intensity ratio, 1.107, 95% confidence interval (CI): 1.080, 1.176), while the intensity of the eligible-to-HIV transition was higher than that for ineligible-to-HIV transition (intensity ratio, 9.558, 95% CI: 0.738, 65.048). The probabilities of transitions increased with time; for 90 days, the probabilities were similar for the ineligible-to-eligible and eligible-to-ineligible transitions (0.285 (95% CI: 0.252, 0.319) vs. 0.258 (95% CI: 0.228, 0.287)), while the eligible-to-HIV transition was more likely than ineligible-to-HIV (0.004 (95% CI: 0.003, 0.007) vs. 0.001 (95% CI: 0.001, 0.008)) but tended to become closer with time. Being classified as ineligible was a short-term indicator of a lower probability of acquiring HIV. Once an individual moved to eligible, he was at a higher risk of seroconversion, demanding a timely delivery ofPrEP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.authenticusidP-00W-9PA
dc.identifier.doi10.1093/aje/kwab260pt_PT
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.slugcv-prod-2606036
dc.identifier.urihttp://hdl.handle.net/10400.26/51020
dc.identifier.wosWOS:000761451100009
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationCentre of Mathematics of the University of Minho
dc.subjectMen who have sex with menpt_PT
dc.subjectHIVpt_PT
dc.subjectPreexposure prophylaxispt_PT
dc.subjectmultistate modelspt_PT
dc.titleTransitions Between Preexposure Prophylaxis Eligibility States and HIV Infection in The Lisbon Cohort of HIV-Negative Men Who Have Sex with Men: a Multistate Model Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleCentre of Mathematics of the University of Minho
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAT%2F00013%2F2013/PT
oaire.citation.titleAmerican Journal Of Epidemiologypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRocha
person.givenNameMiguel
person.identifier999820
person.identifier.ciencia-id5F19-66C4-5F80
person.identifier.orcid0000-0003-1057-2419
person.identifier.ridAAL-7984-2020
person.identifier.scopus-author-id57204739884
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid5F19-66C4-5F80 | Luís Miguel Carvalho Rocha
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf47c1e01-1192-4946-89a8-66594bb7364e
relation.isAuthorOfPublication.latestForDiscoveryf47c1e01-1192-4946-89a8-66594bb7364e
relation.isProjectOfPublication09662f18-3af0-42e5-b288-0a4fccb98a72
relation.isProjectOfPublicationc71e1736-e05e-4243-b449-54f0afce0582
relation.isProjectOfPublication.latestForDiscoveryc71e1736-e05e-4243-b449-54f0afce0582

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