Publication
Optogenetic Activation of Dorsal Raphe Serotonin Neurons Rapidly Inhibits Spontaneous But Not Odor-Evoked Activity in Olfactory Cortex
| dc.contributor.author | Lottem, E. | |
| dc.contributor.author | Lorincz, M. L. | |
| dc.contributor.author | Mainen, Z. F. | |
| dc.date.accessioned | 2018-06-29T15:14:13Z | |
| dc.date.available | 2018-06-29T15:14:13Z | |
| dc.date.issued | 2016-01-06 | |
| dc.description.abstract | Serotonin (5-hydroxytriptamine; 5-HT) is implicated in a variety of brain functions including not only the regulation of mood and control of behavior but also the modulation of perception. 5-HT neurons in the dorsal raphe nucleus (DRN) often fire locked to sensory stimuli, but little is known about how 5-HT affects sensory processing, especially on this timescale. Here, we used an optogenetic approach to study the effect of 5-HT on single-unit activity in the mouse primary olfactory (anterior piriform) cortex. We show that activation of DRN 5-HT neurons rapidly inhibits the spontaneous firing of olfactory cortical neurons, acting in a divisive manner, but entirely spares sensory-driven firing. These results identify a new role for serotonergic modulation in dynamically regulating the balance between different sources of neural activity in sensory systems, suggesting a possible role for 5-HT in perceptual inference. | pt_PT |
| dc.description.sponsorship | ERC 250334, 5-HT Optogenetic | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1523/JNEUROSCI.3008-15.2016 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/23192 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Mice | pt_PT |
| dc.subject | Olfactory Cortex | pt_PT |
| dc.subject | Optogenetics | pt_PT |
| dc.subject | Raphe Nuclei | pt_PT |
| dc.subject | Serotonergic Neurons | pt_PT |
| dc.title | Optogenetic Activation of Dorsal Raphe Serotonin Neurons Rapidly Inhibits Spontaneous But Not Odor-Evoked Activity in Olfactory Cortex | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 18 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 7 | pt_PT |
| oaire.citation.title | Journal of Neuroscience | pt_PT |
| oaire.citation.volume | 36 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |