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Simultaneous analysis of some club drugs in whole blood using solid phase extraction and gas chromatography–mass spectrometry

2012-01-04Journal article Open access
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dc.contributor.authorCastro, André Lobo
dc.contributor.authorTarelho, Sónia
dc.contributor.authorSilvestre, Armando
dc.contributor.authorTeixeira, Helena M.
dc.date.accessioned2023-02-15T16:31:31Z
dc.date.available2023-02-15T16:31:31Z
dc.date.issued2012-01-04
dc.description.abstractThe use of psychoactive substances to improve social relations and increase body energy, in Rave Culture, has raised many legal and health public concerns, both for illicit trade and consumption. Therefore, forensic toxicology plays an important role in this area, mainly linked to the detection and quantitation of these substances, both in vivo and in post-mortem samples. In fact, at the moment, forensic sciences have been under public authorities’ scrutiny and critical look, due to the increasing attention of the media and public opinion, always applying for the use of scientific knowledge to help solving forensic cases. However, forensic toxicology results are only reliable to solve legal cases if all the analytical methodologies used are appropriately validated. In this work, a methodology for the extraction and analysis of 7-aminoflunitrazepam, buprenorphine, flunitrazepam, ketamine, methadone, phencyclidine (PCP) and d-propoxyphene was developed for whole blood samples, with Solid-Phase Extraction (SPE), using OASIS MCX SPE columns, and gas chromatography coupled to mass spectrometry. The procedure presented here proved to be reliable, specific, selective and sensitive, with good LODs and LOQs and good precision.The adoption of a SPE procedure with an automatic SPE extraction device, allowed an increased level of automation in sample treatment, being contemporarily less time-consuming, increasing productiveness, and allowing good recovery and appropriate selectivity being, also, simple and reproducible. The simultaneous detection and quantitation of all compounds by the same extraction and detection methodology is crucial and has a great potential for forensic toxicology and clinical analysis.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationCastro AL, Tarelho S, Silvestre A, Teixeira HM, “Simultaneous analysis of some club drugs in whole blood using solid phase extraction and gas chromatography-mass spectrometry”, Journal of Forensic and Legal Medicine, 19 (2012), 77-82.pt_PT
dc.identifier.doi10.1016/j.jflm.2011.12.006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/43859
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectClub drugspt_PT
dc.subjectSPEpt_PT
dc.subjectWhole bloodpt_PT
dc.subjectGC-MSpt_PT
dc.titleSimultaneous analysis of some club drugs in whole blood using solid phase extraction and gas chromatography–mass spectrometrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage82pt_PT
oaire.citation.startPage77pt_PT
oaire.citation.titleJournal of Forensic and Legal Medicinept_PT
oaire.citation.volume19 (2)pt_PT
person.familyNameLobo Castro
person.familyNameTarelho
person.familyNameDomingues Silvestre
person.familyNameTeixeira
person.givenNameAndré
person.givenNameSónia
person.givenNameArmando Jorge
person.givenNameHelena M.
person.identifierE-6201-2010
person.identifier.ciencia-idDC18-EB22-B357
person.identifier.ciencia-id4214-85EB-E58C
person.identifier.orcid0000-0002-7258-8523
person.identifier.orcid0000-0001-8366-6702
person.identifier.orcid0000-0001-5403-8416
person.identifier.orcid0000-0001-7570-5521
person.identifier.scopus-author-id7005219944
person.identifier.scopus-author-id7003981256
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery04b8f471-69fa-4cc1-942a-7bc7e690a0d4

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