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The amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac death

2019Journal article Open access
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dc.contributor.authorFreitas, P
dc.contributor.authorFerreira, AM
dc.contributor.authorArteaga-Fernández, E
dc.contributor.authorde Oliveira Antunes, M
dc.contributor.authorMesquita, J
dc.contributor.authorAbecasis, J
dc.contributor.authorMarques, H
dc.contributor.authorSaraiva, C
dc.contributor.authorMatos, DN
dc.contributor.authorRodrigues, R
dc.contributor.authorCardim, N
dc.contributor.authorMady, C
dc.contributor.authorRochitte, CE
dc.date.accessioned2020-03-11T22:11:18Z
dc.date.available2020-03-11T22:11:18Z
dc.date.issued2019
dc.description.abstractBACKGROUND: Identifying the patients with hypertrophic cardiomyopathy (HCM) in whom the risk of sudden cardiac death (SCD) justifies the implantation of a cardioverter-defibrillator (ICD) in primary prevention remains challenging. Different risk stratification and criteria are used by the European and American guidelines in this setting. We sought to evaluate the role of cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) in improving these risk stratification strategies. METHODS: We conducted a multicentric retrospective analysis of HCM patients who underwent CMR for diagnostic confirmation and/or risk stratification. Eligibility for ICD was assessed according to the HCM Risk-SCD score and the American College of Cardiology Foundation/American Heart Association (ACCF/AHA) algorithm. The amount of LGE was quantified (LGE%) and categorized as 0%, 0.1-10%, 10.1-19.9% and ≥ 20%. The primary endpoint was a composite of SCD, aborted SCD, sustained ventricular tachycardia (VT), or appropriate ICD discharge. RESULTS: A total of 493 patients were available for analysis (58% male, median age 46 years). LGE was present in 79% of patients, with a median LGE% of 2.9% (IQR 0.4-8.4%). The concordance between risk assessment by the HCM Risk-SCD, ACCF/AHA and LGE was relatively weak. During a median follow-up of 3.4 years (IQR 1.5-6.8 years), 23 patients experienced an event (12 SCDs, 6 appropriate ICD discharges and 5 sustained VTs). The amount of LGE was the only independent predictor of outcome (adjusted HR: 1.08; 95% CI: 1.04-1.12; p <  0.001) after adjustment for the HCM Risk-SCD and ACCF/AHA criteria. The amount of LGE showed greater discriminative power (C-statistic 0.84; 95% CI: 0.76-0.91) than the ACCF/AHA (C-statistic 0.61; 95% CI: 0.49-0.72; p for comparison < 0.001) and the HCM Risk-SCD (C-statistic 0.68; 95% CI: 0.59-0.78; p for comparison = 0.006). LGE was able to increase the discriminative power of the ACCF/AHA and HCM Risk-SCD criteria, with net reclassification improvements of 0.36 (p = 0.021) and 0.43 (p = 0.011), respectively. CONCLUSIONS: The amount of LGE seems to outperform the HCM Risk-SCD score and the ACCF/AHA algorithm in the identification of HCM patients at increased risk of SCD and reclassifies a relevant proportion of patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Cardiovasc Magn Reson. 2019 Aug 15;21(1):50.pt_PT
dc.identifier.doi10.1186/s12968-019-0561-4pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/31692
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCardiomyopathy, Hypertrophic/diagnostic imagingpt_PT
dc.subjectDeath, Sudden, Cardiacpt_PT
dc.subjectGadoliniumpt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectCardiomiopatia Hipertróficapt_PT
dc.subjectMorte Súbita Cardíacapt_PT
dc.subjectGadolíniopt_PT
dc.subjectMedição de Riscopt_PT
dc.titleThe amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac deathpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage50pt_PT
oaire.citation.titleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonancept_PT
oaire.citation.volume21pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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