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Relapsing COVID-19 in a Patient With Non-Hodgkin Lymphoma on Chemotherapy

2023Journal article Open access
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dc.contributor.authorCarujo, A
dc.contributor.authorFerreira, L
dc.contributor.authorBergantim, R
dc.contributor.authorSantos Silva, A
dc.contributor.authorVasconcelos, AL
dc.date.accessioned2024-01-14T17:47:40Z
dc.date.available2024-01-14T17:47:40Z
dc.date.issued2023
dc.description.abstractHematologic malignancies and chemotherapy are risk factors for COVID-19 progression and mortality. Immunocompromised hosts, particularly those with severe B-cell depletion, can shed viable viruses for extended periods, which can lead to persistent infection. We present the case of a 73-year-old male with diffuse large B-cell lymphoma (stage IV-B) under curative immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). After the first episode of mild COVID-19, he developed two severe relapses following the third and fourth cycles of R-CHOP. Lung CT scans performed in both episodes showed new-onset ground-glass infiltrates and fibrosis of previously affected pulmonary segments. In light of similar semiquantitative SARS-CoV-2 viral loads between episodes, without further risk exposure or microbiological findings, persistent COVID-19 with severe clinical relapses was assumed and successfully treated with polyclonal immunoglobulin and remdesivir. Whole-genome sequencing was performed in all samples, confirming the same specimen, which belonged to the B.1.177 lineage. This case stands out for the unusually long viral persistence and the various relapses of severe COVID-19 related to the worsening immune status with each immunochemotherapy cycle.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCureus . 2023 Dec 5;15(12):e49974.pt_PT
dc.identifier.doi10.7759/cureus.49974pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/48902
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCOVID-19pt_PT
dc.subjectLinfoma Não- Hodgkin/tratamentopt_PT
dc.subjectLymphoma, Non-Hodgkin/therapypt_PT
dc.titleRelapsing COVID-19 in a Patient With Non-Hodgkin Lymphoma on Chemotherapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleCureuspt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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