| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 206.45 KB | Adobe PDF |
Advisor(s)
Abstract(s)
The neuropathological hallmark of Parkinson’s disease (PD) is the accumulation of alpha–synuclein (AS) aggregates. The identification of AS aggregates in gut biopsy specimens from people with PD may provide an opportunity to identify PD at a very early stage, prior to symptom onset. Changes in gut microbiota and inflammatory conditions (such as periodontitis) may be linked with PD onset/evolution. This project aims to explore the concept of microbiota–gut–brain axis in PD, studying gut biopsy specimens for AS aggregates, oral and intestinal microbiota, associated digestive disorders and oral health, of both patients with PD and controls.
Description
Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords
Parkinson’s disease alpha-synuclein Microbiota–gut–brain axis
Citation
Grunho M, Godinho C, de Matos AA, Barroso H, Carregosa R, Marx F, Tomé M, Domingos J, Sousa-Catita D, Botelho J, Machado V, Mendes JJ, Outeiro T, Fonseca J. Gut Status in Parkinson’s Disease: The GutSPark Protocol. Medical Sciences Forum. 2021; 5(1):31. https://doi.org/10.3390/msf2021005031
Publisher
MDPI