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Diagnosis and Outcome of Oesophageal Crohn’s Disease

2020Journal article Open access
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dc.contributor.authorVale Rodrigues, R
dc.contributor.authorSladek, M
dc.contributor.authorKatsanos, K
dc.contributor.authorvan der Woude, CJ
dc.contributor.authorWei, J
dc.contributor.authorVavricka, SR
dc.contributor.authorTeich, N
dc.contributor.authorEllul, P
dc.contributor.authorSavarino, E
dc.contributor.authorChaparro, M
dc.contributor.authorBeaton, D
dc.contributor.authorOliveira, AM
dc.contributor.authorFragaki, M
dc.contributor.authorShitrit, AB
dc.contributor.authorRamos, L
dc.contributor.authorKarmiris, K
dc.contributor.authorECCO CONFER investigators
dc.date.accessioned2024-05-08T20:42:24Z
dc.date.available2024-05-08T20:42:24Z
dc.date.issued2020
dc.description.abstractBackground and aims: Crohn's disease [CD] can involve any part of the gastrointestinal tract. We aimed to characterize the clinical, endoscopic and histological features and treatment outcomes of CD patients with oesophageal involvement. Methods: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. Clinical data were recorded in a standardized case report form. Results: A total of 40 patients were reported (22 males, mean [±SD, range] age at oesophageal CD diagnosis: 25 [±13.3, 10-71] years and mean time of follow-up: 67 [±68.1, 3-240] months). Oesophageal involvement was established at CD diagnosis in 26 patients [65%] and during follow-up in 14. CD was exclusively located in the oesophagus in two patients. Thirteen patients [32.2%] were asymptomatic at oesophageal disease diagnosis. Oesophageal strictures were present in five patients and fistulizing oesophageal disease in one. Eight patients exhibited granulomas on biopsies. Proton-pump inhibitors [PPIs] were administered in 37 patients [92.5%]. Three patients underwent endoscopic dilatation for symptomatic strictures but none underwent oesophageal-related surgery. Diagnosis in pre-established CD resulted in treatment modifications in 9/14 patients. Clinical remission of oesophageal disease was seen in 33/40 patients [82.5%] after a mean time of 7 [±5.6, 1-18] months. Follow-up endoscopy was performed in 29/40 patients and 26/29 [89.7%] achieved mucosal healing. Conclusion: In this case series the endoscopic and histological characteristics of isolated oesophageal CD were similar to those reported in other sites of involvement. Treatment was primarily conservative, with PPIs administered in the majority of patients and modifications in pre-existing inflammatory bowel disease-related therapy occurring in two-thirds of them. Clinical and endoscopic remission was achieved in more than 80% of the patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crohns Colitis . 2020 Jun 19;14(5):624-629.pt_PT
dc.identifier.doi10.1093/ecco-jcc/jjz201pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/50798
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectDoença de Crohnpt_PT
dc.subjectCrohn Diseasept_PT
dc.titleDiagnosis and Outcome of Oesophageal Crohn’s Diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage629pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage624pt_PT
oaire.citation.titleJournal of Crohn's and Colitispt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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