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A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation

2016Journal article Open access
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dc.contributor.authorPais-Vieira, M
dc.contributor.authorYadav, AP
dc.contributor.authorMoreira, D
dc.contributor.authorGuggenmos, D
dc.contributor.authorSilva-dos-Santos, A
dc.contributor.authorLebedev, M
dc.contributor.authorNicolelis, ML
dc.date.accessioned2016-09-12T21:42:21Z
dc.date.available2016-09-12T21:42:21Z
dc.date.issued2016
dc.description.abstractAlthough electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.pt_PT
dc.identifier.citationSci Rep. 2016 Sep 8;6:32814.pt_PT
dc.identifier.doi10.1038/srep32814pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/14650
dc.language.isoengpt_PT
dc.subjectEstimulação Eléctricapt_PT
dc.subjectEpilepsiapt_PT
dc.titleA Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage32814pt_PT
oaire.citation.volume6pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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