Publication
Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment
| dc.contributor.author | Badura, Robert | |
| dc.contributor.author | Foxall, Russell B. | |
| dc.contributor.author | Ligeiro, Dario | |
| dc.contributor.author | Rocha, Miguel | |
| dc.contributor.author | Godinho-Santos, Ana | |
| dc.contributor.author | Trombetta, Amelia C. | |
| dc.contributor.author | Sousa, Ana E. | |
| dc.date.accessioned | 2024-06-17T15:56:52Z | |
| dc.date.available | 2024-06-17T15:56:52Z | |
| dc.date.issued | 2020-07-16 | |
| dc.date.updated | 2024-06-10T12:53:23Z | |
| dc.description.abstract | HIV-1 infection induces B cell defects, not fully recovered upon antiretroviral therapy (ART). Acute infection and the early start of ART provide unique settings to address the impact of HIV on the B cell compartment. We took advantage of a cohort of 21 seroconverters, grouped according to the presence of severe manifestations likely mediated by antibodies or immune complexes, such as Guillain-Barré syndrome and autoimmune thrombocytopenic purpura, with a follow-up of 8 weeks upon effective ART. We combined B and T cell phenotyping with serum immunoglobulin level measurement and quantification of sj-KRECs and ΔB to estimate bone marrow output and peripheral proliferative history of B cells, respectively. We observed marked B cell disturbances, notably a significant expansion of cells expressing low levels of CD21, in parallel with markers of both impaired bone marrow output and increased peripheral B cell proliferation. This B cell dysregulation is likely to contribute to the severe immune-mediated conditions, as attested by the higher serum IgG and the reduced levels of sj-KRECs with increased ΔB in these individuals as compared to those patients with mild disease. Nevertheless, upon starting ART, the dynamic of B cell recovery was not distinct in the two groups, featuring both persistent alterations by week 8. Overall, we showed for the first time that acute HIV-1 infection is associated with decreased bone marrow B cell output assessed by sj-KRECs. Our study emphasizes the need to intervene in both bone marrow and peripheral responses to facilitate B cell recovery during acute HIV-1 infection. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.authenticusid | P-00S-J4S | |
| dc.identifier.doi | 10.3389/fcimb.2020.00347 | pt_PT |
| dc.identifier.eid | 2-s2.0-85088815505 | |
| dc.identifier.issn | 2235-2988 | |
| dc.identifier.pmid | 32766164 | |
| dc.identifier.slug | cv-prod-1972245 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/51058 | |
| dc.identifier.wos | WOS:000556771400001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Men who have sex with men | pt_PT |
| dc.subject | HIV | pt_PT |
| dc.title | Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Frontiers in Cellular and Infection Microbiology | pt_PT |
| oaire.citation.volume | 10 | pt_PT |
| person.familyName | Rocha | |
| person.givenName | Miguel | |
| person.identifier | 999820 | |
| person.identifier.ciencia-id | 5F19-66C4-5F80 | |
| person.identifier.orcid | 0000-0003-1057-2419 | |
| person.identifier.rid | AAL-7984-2020 | |
| person.identifier.scopus-author-id | 57204739884 | |
| rcaap.cv.cienciaid | 5F19-66C4-5F80 | Luís Miguel Carvalho Rocha | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | f47c1e01-1192-4946-89a8-66594bb7364e | |
| relation.isAuthorOfPublication.latestForDiscovery | f47c1e01-1192-4946-89a8-66594bb7364e |