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Laboratory Assessment of the Effects of AGA@4life Multidisciplinary Intervention on the Inflammatory Profile, MMPs, and TIMPs in a Geriatric Population

2024-02-21Journal article Open access
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dc.contributor.authorLourenço, Ana Patrícia
dc.contributor.authorFreitas, Catarina
dc.contributor.authorTimóteo, Maria Helena
dc.contributor.authorSoares, Maria
dc.contributor.authorFigueiredo, João
dc.contributor.authorOsório, Nádia
dc.contributor.authorValado, Ana
dc.contributor.authorTrapali, Maria
dc.contributor.authorPereira, Telmo
dc.contributor.authorCaseiro, Armando
dc.date.accessioned2024-02-28T12:25:36Z
dc.date.available2024-02-28T12:25:36Z
dc.date.issued2024-02-21
dc.description.abstractAbstract: In recent years, the world’s aging population has increased, contributing to the development of age-related pathologies, which have been aggravated by physical inactivity and excessive fat intake. This study aimed to evaluate the effect of implementing a nutritional program (control group—CG) combined with exercise (intervention group—IG) on the inflammatory profile, MMPs, and TIMPs in a group of 34 elderly participants (IG, n = 18; CG, n = 16). Participants underwent a full multidisciplinary diagnostic evaluation (T0), with the gathering of clinical information and biochemical and hematological determinations being re-evaluated eight weeks later (T1). A diet manual was made, which provided a selection of different types of diets resulting from the nutritional needs of the different users at the center. The aerobic exercise consisted of two sessions per week with a total duration of 1 h. The laboratory evaluation was performed by slot blot. Statistical analysis included a paired sample t-test and Spearman’s correlation coefficient. We observed that in the IG, there was a significant increase at T1 of TNF-α (p < 0.05) and MMP-2 (p < 0.05), without changes in IL-6 and MMP-9, showing that the intervention did not cause an exacerbated inflammatory response in exercised elderly people. The intervention program implemented showed potential to contribute to better active aging strategies, taking advantage of the known benefits of exercise without inducing a harmful inflammatory response in elderly participants.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.3390/healthcare12050509pt_PT
dc.identifier.issn2227-9032
dc.identifier.urihttp://hdl.handle.net/10400.26/50077
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2227-9032/12/5/509pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAgingpt_PT
dc.subjectIL-6pt_PT
dc.subjectTNF-αpt_PT
dc.subjectMMPspt_PT
dc.subjectTIMPspt_PT
dc.subjectEnvelhecimentopt_PT
dc.subjectInterleucina-6pt_PT
dc.subjectMetaloproteinases da matrizpt_PT
dc.subjectInibidores teciduais de metaloproteinasespt_PT
dc.subjectFator de necrose tumoral alfapt_PT
dc.titleLaboratory Assessment of the Effects of AGA@4life Multidisciplinary Intervention on the Inflammatory Profile, MMPs, and TIMPs in a Geriatric Populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.titleHealthcarept_PT
oaire.citation.volume12pt_PT
person.familyNameOsório
person.familyNameValado
person.familyNamePereira
person.familyNameCaseiro
person.givenNameNádia
person.givenNameAna Maria
person.givenNameTelmo
person.givenNameArmando
person.identifier779139
person.identifier.ciencia-id271E-2D9B-E7F3
person.identifier.ciencia-idF217-BA65-C0D2
person.identifier.ciencia-idEB19-9F1B-9811
person.identifier.ciencia-id4012-A0D8-66D6
person.identifier.orcid0000-0001-9559-2165
person.identifier.orcid0000-0002-0157-6648
person.identifier.orcid0000-0001-9119-7774
person.identifier.orcid0000-0001-7844-0506
person.identifier.ridM-4626-2013
person.identifier.ridL-8385-2013
person.identifier.scopus-author-id57188973499
person.identifier.scopus-author-id24391294200
person.identifier.scopus-author-id35738464000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf98c6cd7-be5f-4d66-bbf5-7ae3746e3d6b
relation.isAuthorOfPublication5b2f32e0-3079-4552-8dd7-10358151e281
relation.isAuthorOfPublication85969647-47cc-47ee-bec2-1360f30ae958
relation.isAuthorOfPublication3736a1f3-88d6-42fb-94fc-ecd5484412de
relation.isAuthorOfPublication.latestForDiscoveryf98c6cd7-be5f-4d66-bbf5-7ae3746e3d6b

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