Browsing by resource type "clinical study"
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- O fenómeno da língua vilosa nigraPublication . Limbert, M; Amaral, F; Maio, P; Rebelo, D
- Information Technology in Nursing Practice: A Scoping Review of Assessment Tools for Evaluating Nurses' CompetenciesPublication . Cachata, D; Costa, M; Magalhães, T; Lucas, P; Gaspar, FIntroduction: The ongoing evolution of Health Information Technology has provided professionals with major challenges in maintaining the safety and quality of care provided to patients, especially when it comes to hyper-technological environments in hospital. This has driven the need to develop specific competencies and maintain a balance between ethical aspects, social and legal challenges related to privacy and data security, as well as the challenge of ensuring person-centered care practice. Then it will be important to understand what competences nurses are developing, based on what models and what instruments exist to assess them. Purpose: Identify and map information technologies and measurement instruments used to assess nurses' competencies in technological environments in hospital. Methods: A scoping review was carried out using the methodology presented by The Joanna Briggs Institute. Results: Of the 101 articles extracted, 4 articles were selected where 5 instruments were identified that evaluate: (1) Informatics Competency in Nursing Leaders; (2) Technological Competence as Nursing Care - Perception and Practice dimension; (3) Self-Assessment of Nursing Informatics Skills; (4) Clinical Decision Making in Nursing, and (5) Self-Assessment Questionnaire that Assesses Nurses' Informatics Skills, for nursing informatics. Conclusion: The development and enhancement of technological skills in nursing care provide an innovative and crucial perspective for managing and organizing healthcare delivery. This perspective is of great importance, reinforced by the reality in which nurses find themselves, with highly technological nursing practice environments that are increasingly developed. Knowledge and use of IT equipment, areas of basic IT knowledge, information literacy, wireless device skills, the role of clinical IT, and applied IT skills are some of the skills identified by this study. The use of various support tools as instruments for clinical decision-making in nursing is also fundamental to the quality of nursing care.
- Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status and Diagnostic ChallengesPublication . Fernandes, I; Macedo, D; Gouveia, E; Ferreira, A; Lima, J; Lopez, D; Melo-Alvim, C; Carvalho, A; Tavares, P; Rodrigues-Santos, P; Cardoso, P; Magalhães, M; Vieira, P; Brito, J; Mendes, C; Rodrigues, J; Netto, E; Oliveira, V; Sousa, C; Henriques Abreu, M; Pina, F; Vasques, HSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/predictive biomarkers, namely the neurotrophic tyrosine receptor kinase (NTRK) gene fusion. The NTRK fusion assessment has recently become a standard part of management for patients with unresectable locally advanced or metastatic cancers and has been identified in various tumor types. In the more prevalent adult and pediatric sarcomas, NTRK fusions are present in 1% and 20%, respectively, and in more than 90% of very rare subsets of tumors. The inhibition of TRK activity with first-generation TRK inhibitors has been found to be effective and well tolerated in adult and pediatric patients, independently of the tumor type. Overall, the therapeutic benefit to those patients compensates for the difficulties of identifying NTRK gene fusions. However, the rarity and diagnostic complexity of NTRK gene fusions raise several questions and challenges for clinicians. To address these issues, an expert panel of medical and pediatric oncologists, radiologists, surgeons, orthopedists, and pathologists reviewed the recent literature and discussed the current status and challenges, proposing a diagnostic algorithm for identifying NTRK fusion sarcomas. The aim of this article is to review the updated information on this issue and to provide the experts' recommendations and practical guidance on the optimal management of patients with soft tissue sarcomas, infantile fibrosarcoma, gastrointestinal stromal tumors, and osteosarcoma.