Repository logo

Browsing by Author "Vaccaro, CA"

Now showing 1 - 1 of 1
  • Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)
    Publication . Temmink, SJ; Peeters, KC; Bahadoer, R; Kranenbarg, MK; Roodvoets, AG; Melenhorst, J; Burger, JW; Wolthuis, A; Renehan, AG; Figueiredo, NL; Pares, Or; Martling, A; Perez, RO; Beets, GL; van de Velde, CJ; Nilsson, PJ; Aghili, M; Keshvari, A; Nouritaromlou, MK; Ahlberg, M; Kordnejad, S; Aleinikov, A; Dulskas, A; Asoğlu, O; Tokmak, H; Barroca, RG; Caiado, AF; Rosa, IA; Breukink, SO; Coraglio, MF; Iseas, S; Creaven, B; Winter, DC; Zaborowski, A; Cunningham, C; Gregory, E; Custers, PA; Geubels, BM; DeBrun, L; D’Hoore, A; Dimofte, G; Fechner, K; Matzel, K; Fernandez, L; Herrando, AI; Vieira, P; Gaertner, WB; Madoff, RD; Gerard, JP; Jacquinot, F; Schiappa, R; Gollins, S; Gonzalez, M; Vaccaro, CA; Habr-Gama, A; São Julião, G; Holman, FA; Hompes, R; Lameris, W; Ketelaers, SH; Rutten, HJ; Leitner, K; Mazzarisi, C; Malcomson, L; O’Dwyer, ST; Saunders, M; Maroli, A; Mitchell, P; Murad-Regadas, S; Pairola, A; Pedraza, SI; Sanchez, LF; Pennings, AJ; Spinelli, A; Sun, MA
    Background: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wait Database. Patients were categorized as having a cCR at first reassessment or at later reassessment (that is near-cCR at first reassessment) based on MRI and endoscopy. Organ preservation, distant metastasis-free survival, and overall survival rates were calculated. Subgroup analyses were done for near-cCR groups based on the response evaluation according to modality. Results: A total of 1010 patients were identified. At first reassessment, 608 patients had a cCR; 402 had a cCR at later reassessment. Median follow-up was 2.6 years for patients with a cCR at first reassessment and 2.9 years for those with a cCR at later reassessment. The 2-year organ preservation rate was 77.8 (95 per cent c.i. 74.2 to 81.5) and 79.3 (75.1 to 83.7) per cent respectively (P = 0.499). Similarly, no differences were found between groups in distant metastasis-free survival or overall survival rate. Subgroup analyses showed a higher organ preservation rate in the group with a near-cCR categorized exclusively by MRI. Conclusion: Oncological outcomes for patients with a cCR at later reassessment are no worse than those of patients with a cCR at first reassessment.
    2023Journal article Open access Show more