Browsing by Author "Ribeiro, A. C."
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- APOBEC3 host factors modulate viral production and infectivity of HIV-2Publication . Bandarra, S.; Ribeiro, A. C.; Gomes, P.; Gonçalves, J.; Barahona, I.
- CYP3A5 genetic polymorphism in HIV-patientsPublication . Fernandes, A.; Cruz, J. P.; Martins, R.; Morais, J. G.; Ribeiro, A. C."A number of relevant polymorphisms are known for affecting the most common prescribed ARVs (antiretroviral), inducing drug toxicity, risk of virologic failure and may explain the interpatient variability for drug absorption pathways. CYP3A5 is an isoform of Cytochromes P4503A family, estimated to participate in the metabolism of 40 to 60% of all clinically administered drugs, namely atazanavir (1). The aim of this study was to characterize the CYP3A5 polymorphisms of HIV infected patients, from Santa Maria Hospital, Lisbon, Portugal."
- Cytotoxic and genotoxic effects of three cements used in fixed prosthesisPublication . Paraíso, A.; Neves, J.; Bandarra, S.; Mascarenhas, P.; Bekman, E.; Ribeiro, A. C.; Félix, S.; Barahona, I.
- Effects of three current provisional restoration materials on fibroblast viabilityPublication . Luís, A. R.; Bandarra, S.; Bekman, E.; Mascarenhas, P.; Pacheco, I.; Ribeiro, A. C.; Caldeira, J.; Félix, S.; Barahona, I.
- HIV-2 viral production and infectivity are affected by APO3 host factorsPublication . Bandarra, S.; Ribeiro, A. C.; Gonçalves, J.; Barahona, I.
- Pharmacogenetic: screening relevant polymorphisms on antiretroviral therapy in a HIV Portuguese populationPublication . Fernandes, A.; Cruz, J. P.; Paixão, P.; Valadas, E.; Morais, J. G.; Ribeiro, A. C."Several factors cause heterogeneity of response to antiretroviral therapy. Genetic polymorphisms, particularly in metabolizing enzyme, cytochrome P450 isoenzymes and transport proteins MDR, MRP and SLC, may cause pharmacokinetic variability in some ARVs, leading to viral failure, drug toxicity and may explain the interpatient variability for drug absorption pathways."
- Searching for the G516T Polymorphism on the CYP2B6 gene in HIV-1PatientsPublication . Fernandes, A.; Aniceto, N.; Cruz, J. P.; Paixão, P.; Valadas, E.; Morais, J. G.; Ribeiro, A. C.
- Searching relevant polymorphisms of CYP2B6 in HIV infected patientsPublication . Tomaz, R.; Fernandes, A.; Cruz, J. P.; Martins, R.; Morais, J. G.; Ribeiro, A. C."The CYP2B6 belongs to the family of Cytochrome P450 enzymes that catalyze the metabolism of a wide variety of drugs, including the anti-retroviral EFV. The CYP2B6 gene, that has been mapped in the chromosome 19, is highly polymorphic and some SNP, namely 516G>T and 785A>G, are associated with decreased protein expression. These variants are related to phenotypes that are characterized as EFV poor metabolizers, and consequently to episodes of neurotoxicity."