Browsing by Author "Resende, Luís"
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- Renal Disease in Madera Islands: twenty years experience of native kidney biopsiesPublication . Vieira, Pedro; Goncalves, Miguel; Durães, José; Rosa, Nuno; Resende, Luís; Silva, Gil; Teixeira, Alves; Rodrigues, Fernando; Galvão, Maria; Brinca, Ana; Viana, Helena; Carvalho, Fernanda; Araújo, JoséRenal biopsy plays an essential role either in the diagnosis or in the prognosis of patients with renal disease. In order to assess its epidemiology and evolution in Madeira Islands, we analysed twenty-seven years of native kidney biopsies. Methods: We performed a retrospective analysis of clinical records, including histological revision from 1986 to 2012, totalling 315 native kidney biopsies. They were assessed regarding the temporal evolution both for the quality/indications for renal biopsy and for the patterns of kidney disease. Results: A total of 315 native kidney biopsies were analysed. The patients’ mean age was of 40.8 ± 18.4 years and 50.5%(n = 159) were males. The most common indications for renal biopsy were nephrotic syndrome (36.2%, n = 114) and acute kidney injury (20.0%, n = 63). Among primary glomerular diseases (41.5%, n = 115) the most common were IgA nephropathy (26.1%, n = 30) and focal-segmental glomerulosclerosis (17.4%, n = 20) and among secondary glomerular diseases (31.4%, n = 87), lupus nephritis (51.7%, n = 45) and amyloidosis (20.7%, n = 18). Statistical analysis revealed significant correlation between gender and major pathological diagnosis (Fisher’s exact test, p <.01) and between indications for renal biopsy and major pathological diagnosis (χ2, p <.01). Regarding the temporal evolution, no statistically significant differences were found in the number of renal biopsies (χ2, p =.193), number of glomeruli per sample (Fisher’s exact test, p =.669), age (Kruskal-Wallis, p =.216), indications for renal biopsy (χ2, p =.106) or major pathological diagnosis groups (χ2, =.649). However, considering the specific clinico-pathological diagnoses and their temporal variation, a statistically significant difference (Fisher’s exact test, p <.05) was found for lupus nephritis and membranous nephropathy with an increasing incidence and for amyloidosis with an opposite tendency. Discussion: The review of the native kidney biopsies from a population with particular characteristics, geographically isolated, such as those from Madeira Islands, showed parallel between epidemiological numbers referring to other
- Salmonella peritonitis in an automated peritoneal dialysis patient- Case reportPublication . Carvão, João; Resende, Luís; Vida, Carlota; Silva, Francisca; Durães, José; Silva, GilPeritonitis remains one of the main complications of peritoneal dialysis (PD) and one of the main reasons for abandoning this treatment and switching to hemodialysis. It also accounts for considerable mortality and hospitalization among PD patients. Most cases of peritonitis related to PD result from the contamination caused by the poor management of the Tenckhoff catheter by the patient or care-provider. The most frequently associated agents are coagulase-negative Staphylococcus and Staphylococcus aureus. However, Gram-negative bacteria and fungi may also be the cause of peritonitis.1 Salmonella is an intracellular pathogen member of the Enterobacteriaceae family, and it is an extremely rare agent causing peritonitis (0.15%),2 with the particularity of being an extremely complicated organism to eradicate,3 and in most of the cases described, it was necessary to remove the Tenckhoff catheter. Literature is scarce on the ideal therapeutic approach….etc.