Browsing by Author "Costa, Isabel Margarida"
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- Alcohol-antibacterial drug interactions: comparison of three drug compendiaPublication . Lança, Teresa; Auxtero, Deolinda; Costa, Isabel Margarida; Guerreiro, Mara Pereira
- Alergias “Alimentares” a MedicamentosPublication . Santo, Maria; Brás, Adriana; Casimiro, Andreia; Auxtero, Maria Deolinda; Figueiredo, Alexandra; Costa, Isabel Margarida
- Allergens in medicines: soybean and glutenPublication . Brás, Adriana; Auxtero, Maria Deolinda; Figueiredo, Alexandra; Costa, Isabel Margarida; Costa, Isabel MargaridaPoster apresentado no XX Congresso de Nutrição e Alimentação & II Congresso Internacional de Nutrição e Alimentação (Associação Portuguesa de Nutrição). Online, 23-24 setembro 2021
- An overview of vitamin B in food supplementsPublication . Costa, Isabel Margarida; Figueiredo, Alexandra; Auxtero, Maria Deolinda
- Ansiedade: abordagem farmacológica e padrões de consumo em França e Portugal : estudo exploratórioPublication . Baúto, Ricardo; Silva, Jean Noel da; Figueiredo, Alexandra; Costa, Isabel Margarida; Costa, Isabel Margarida; Figueiredo, AlexandraPoster apresentado no Congresso Internacional de Saúde Mental no Jovem Adulto. Coimbra, 27 e 28 de março de 2025
- Bridging generations through integrative learning, research, and community care : The ESPIEM ProjectPublication . Auxtero, Maria Deolinda; Costa, Isabel Margarida; Brito, José; Figueiredo, Alexandra; Ascenso, Carla; Miranda, Margarida; Caneiras, Cátia; Fernandes, Ana IsabelCommunication abstract presented at the EAFP Annual Conference 2025 – “Pharmaceutical Education & Research: SWOT Analysis”. Faculty of Pharmacy, University of Coimbra, 13th-15th of May 2025
- Cow’s milk protein allergy: the hidden danger of medicines’ excipientsPublication . Santo, Maria; Auxtero, Maria Deolinda; Figueiredo, Alexandra; Costa, Isabel MargaridaIn patients with a cow’s milk protein allergy, the presence of these allergens in medicines, even in trace amounts, can trigger serious allergic reactions. The study of milk-related excipient prevalence in 165 antiasthmatic medicines, based on the information included in the Summary of Product Characteristics, revealed the presence of lactose in more than one third of these medicines. Since lactose may suffer cross-contamination with cow’s milk protein, these results are an alert to health professionals.
- Fat-soluble vitamins in food supplements: do the labels follow the recommended doses?Publication . Costa, Isabel Margarida; Figueiredo, Alexandra; Moutinho, Guilhermina Martins; Auxtero, Maria DeolindaPoster presented at the 3rd International Congress of CiiEM: Research and Innovation in Human & Health Sciences. Caparica, 20 june 2018
- Feasibility of wavelength dispersive X-ray fluorescence spectrometryfor the determination of metal impurities in pharmaceutical productsand dietary supplements in view of regulatory guidelinesPublication . Figueiredo, Alexandra; Fernandes, Tânia; Costa, Isabel Margarida; Gonçalves, Luísa; Brito, JoséThe aim of this study was to investigate the feasibility of Wavelength Dispersive X-ray Fluorescence (WDXRF) spectrometry for the measurement of As, Cd, Cr, Cu, Hg, Ir, Mn, Mo, Ni, Os, Pb, Pd, Pt, Rh, Ru and V impurities in pharmaceuticals and dietary supplements, in view of the requirements by EMA and USP for the measurement of elemental impurities in drug products and according to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH guidelines). For that purpose, a 4 kW WDXRF spectrometer (S4 Pioneer, Bruker AXS) was used after system calibration. The linearity of the method was demonstrated by correlation coefficients in excess of 0.9 and by appropriate test of lack of fit, except for Cd, Hg, Pd, V and As, which were excluded from analysis. The calculated limits of detection and quantification were in the ranges 0.6-5.4 μg/g and 1.7-16.4 μg/g meeting defined acceptance criteria, except for Pb. The accuracy of the method, determined by the percent recovery (R) of known amounts of each element added to a selected drug, at 3 different concentration levels, was in the acceptance range 70-150% except for Os and Pt, in which case R was marginally outside that range. The repeatability of the method, assessed as the % residual standard deviation (%RSD) of 3 replicate measurements at 3 concentration levels, produced %RSD values lower than 20%, as required. These results show that the WDXRF method complies with the validation requirements defined by the European Pharmacopeia for Cu, Cr, Ir, Mn, Mo, Ni, Os, and Pt, and by the United States Pharmacopeia for Ir, Ni, Os and Pt. Therefore, it may be an alternative to the compendial analytical procedures recommended for such elements. The novelty of the present work is the application of WDXRF to final medicines and not only to active pharmaceutical ingredients and/or excipients.
- Food allergens in oral care productsPublication . Coimbra, Luísa; Costa, Isabel Margarida; Evangelista, José Grillo; Figueiredo, AlexandraFood allergies are a growing concern, especially in Western societies and can dramatically impact the quality of life of affected individuals. In recent years, various food allergens have been introduced into the oral care industry to improve product properties and provide the best possible treatment. Since small doses of food allergens may be sufficient to trigger allergic reactions, the non-discrimination of the sources of certain excipients in the product composition can compromise the patient's health. Therefore, knowledge and awareness of allergies and product composition among health professionals are critical on behalf of patients’ and consumers’ health. This study aimed to ascertain the presence of dairy products (e.g., cow's milk proteins and lactose), cereals (e.g., gluten, soy, and oats), fruits, nuts, spices, shellfish, and additives as excipients in oral care products for outpatients and products for professional use in the Dental Office. Among the 387 surveyed products, the highest prevalence of food allergens was found in toothpaste, fluoride varnishes, and alginates, mostly in spices and fresh fruits. As food allergies may occur because of erroneous information or a lack of labeling on the allergen list, manufacturers should be more rigorous in declaring allergens on product labeling regarding the safety of consumers.