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Publication
Terapêutica com Células Estaminais na Mielopatia Degenerativa no Cão
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Advisor(s)
Abstract(s)
A Mielopatia Degenerativa é uma doença neurodegenerativa fatal que afeta cães, com
prognóstico grave. Esta doença tem origem numa mutação genética do gene SOD1, a mesma
responsável pela Esclerose Lateral Amiotrófica (ELA) nos humanos. A prevalência é elevada em
cães da raça Pastor Alemão. Inicialmente manifesta-se por uma ataxia propriocetiva nos
membros pélvicos, evoluindo para uma atrofia muscular grave, com ausência de reflexos
espinhais, culminando com a morte do doente. A confirmação do diagnóstico de Mielopatia
Degenerativa (MD) é feita através de um teste genético. A aplicação de um plano terapêutico
associando a neuroreabilitação funcional (NRF) e a utilização de células estaminais, permite
manter a funcionalidade e autonomia do cão por mais tempo, atrasando a progressão da
doença, oferecendo qualidade de vida e bem-estar ao doente. O presente relatório finaliza o
estágio curricular realizado no Hospital Veterinário da Arrábida e Centro de Reabilitação
Animal da Arrábida. Com este estágio, que teve a duração de três meses, foram desenvolvidas
e adquiridas diversas competências teórico-práticas, que cimentaram conhecimentos
adquiridos em contexto escolar. Foi possível, com a realização do estágio, participar de forma
direta, em diversas áreas de atuação do enfermeiro veterinário. A dinâmica e a dimensão do
local de estágio permitiram o contacto com alta e diversificada casuística. Foi dada especial
importância ao acompanhamento de dois cães homozigóticos com MD, Border Collie e Pastor
Alemão, ao nível da aplicação do protocolo de reabilitação, e da utilização da terapêutica
experimental com células estaminais alógenas em soro autólogo. A implementação das células
estaminais foi benéfica para os doentes, devido às suas caraterísticas específicas, no entanto,
após dois meses da administração das células, os doentes regrediram, devido à evolução
natural da MD.
Degenerative Myelopathy is a fatal neurodegenerative disease that affects dogs, with a severe prognosis. This disease originates from a genetic mutation in the SOD1 gene, the same one responsible for Amyotrophic Lateral Sclerosis (ELA) in humans. The prevalence is high in dogs of the German Shepherd breed. Initially, it manifests as proprioceptive ataxia in the pelvic limbs, progressing to severe muscle atrophy, with an absence of spinal reflexes, culminating in the patient's death. Confirmation of the diagnosis of Degenerative Myelopathy (MD) is done through a genetic test. The application of a therapeutic plan associating functional neurorehabilitation (NRF) and the use of stem cells allows the dog to maintain its functionality and autonomy for a longer time, delaying the progression of the disease, offering quality of life and well-being to the patient. This report concludes the curricular internship carried out at the Hospital Veterinário da Arrábida and Centro de Reabilitação Animal da Arrábida. With this internship, which lasted three months, several theoretical and practical skills were developed and acquired, which cemented knowledge acquired in the school context. It was possible, with the completion of the internship, to participate directly in several areas of work of the veterinary nurse. The dynamics and dimension of the internship site allowed contact with a large and diverse sample. Special importance was given to the monitoring of two homozygous dogs with MD, Border Collie and German Shepherd, in terms of the application of the rehabilitation protocol, and the use of experimental therapy with allogeneic stem cells in autologous serum. The implementation of stem cells was beneficial to patients, due to their specific characteristics, however, after two months of administration of the cells, patients regressed, due to the natural evolution of MD.
Degenerative Myelopathy is a fatal neurodegenerative disease that affects dogs, with a severe prognosis. This disease originates from a genetic mutation in the SOD1 gene, the same one responsible for Amyotrophic Lateral Sclerosis (ELA) in humans. The prevalence is high in dogs of the German Shepherd breed. Initially, it manifests as proprioceptive ataxia in the pelvic limbs, progressing to severe muscle atrophy, with an absence of spinal reflexes, culminating in the patient's death. Confirmation of the diagnosis of Degenerative Myelopathy (MD) is done through a genetic test. The application of a therapeutic plan associating functional neurorehabilitation (NRF) and the use of stem cells allows the dog to maintain its functionality and autonomy for a longer time, delaying the progression of the disease, offering quality of life and well-being to the patient. This report concludes the curricular internship carried out at the Hospital Veterinário da Arrábida and Centro de Reabilitação Animal da Arrábida. With this internship, which lasted three months, several theoretical and practical skills were developed and acquired, which cemented knowledge acquired in the school context. It was possible, with the completion of the internship, to participate directly in several areas of work of the veterinary nurse. The dynamics and dimension of the internship site allowed contact with a large and diverse sample. Special importance was given to the monitoring of two homozygous dogs with MD, Border Collie and German Shepherd, in terms of the application of the rehabilitation protocol, and the use of experimental therapy with allogeneic stem cells in autologous serum. The implementation of stem cells was beneficial to patients, due to their specific characteristics, however, after two months of administration of the cells, patients regressed, due to the natural evolution of MD.
Description
Keywords
Mielopatia Degenerativa no Cão Teste genético Neuroreabilitação Funcional Implementação de células estaminais Dog Degenerative Myelopathy Genetic testing Functional Neurorehabilitation Stem cell implementation
Citation
Semedo, M.J.E.(2022).Terapêutica com Células Estaminais na Mielopatia Degenerativa no Cão. Escola Superior Agrária de Elvas. Elvas
Publisher
Escola Superior Agrária de Elvas