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Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island

2017Journal article Open access
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dc.contributor.authorSousa, Ana Célia
dc.contributor.authorPalma dos Reis, Roberto
dc.contributor.authorPereira, Andreia
dc.contributor.authorBorges, Sofia
dc.contributor.authorFreitas, Ana Isabel
dc.contributor.authorGuerra, Graça
dc.contributor.authorGóis, Teresa
dc.contributor.authorRodrigues, Mariana
dc.contributor.authorHenriques, Eva
dc.contributor.authorFreitas, Sónia
dc.contributor.authorOrnelas, Ilídio
dc.contributor.authorPereira, Décio
dc.contributor.authorBrehm, António
dc.contributor.authorMendonça, Maria Isabel
dc.date.accessioned2019-02-21T10:31:45Z
dc.date.available2019-02-21T10:31:45Z
dc.date.issued2017
dc.description.abstractEssential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls. Cases and controls were matched for sex and age, by frequency-matching method. All participants collected blood for biochemical and genotypic analysis for the Gly460Trp polymorphism. We further investigated which variables were independently associated to EH, and, consequently, analyzed their interactions.In our study, we found a significant association between the ADD1 gene polymorphism and EH (odds ratio 2.484, P = .01). This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population. The knowledge of genetic polymorphisms associated with EH is of paramount importance because it leads to a better understanding of the etiology and pathophysiology of this pathology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, A. C., dos Reis, R. P., Pereira, A., Borges, S., Freitas, A. I., Guerra, G., ... & Ornelas, I. (2017). Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island. Medicine, 96(42).pt_PT
dc.identifier.doi10.1097/MD.0000000000007861pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/27891
dc.language.isoengpt_PT
dc.publisherWolters Kluwer Healthpt_PT
dc.subjectCalmodulin-Binding Proteinspt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectEssential Hypertensionpt_PT
dc.subjectGenetic Predisposition to Diseasept_PT
dc.subjectMultivariate Analysispt_PT
dc.subjectOdds Ratiopt_PT
dc.subjectPortugalpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectPolymorphism, Geneticpt_PT
dc.subjectADD1 genept_PT
dc.subjectMadeira Islandpt_PT
dc.titleRelationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Islandpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue42pt_PT
oaire.citation.startPagee7861pt_PT
oaire.citation.volume96pt_PT
person.familyNameSousa
person.familyNameReis
person.familyNamepereira
person.familyNameBorges
person.familyNameRodrigues
person.familyNameHenriques
person.familyNameFreitas
person.familyNameMendonca
person.givenNameAna Célia
person.givenNameRoberto
person.givenNameandreia
person.givenNameSofia
person.givenNameMariana Rodrigues
person.givenNameEva
person.givenNameSónia
person.givenNameMaria Isabel
person.identifier.orcid0000-0002-2069-0278
person.identifier.orcid0000-0003-2803-8193
person.identifier.orcid0000-0001-5129-2478
person.identifier.orcid0000-0002-9413-7942
person.identifier.orcid0000-0001-7280-0021
person.identifier.orcid0000-0002-7312-5272
person.identifier.orcid0000-0001-5204-8928
person.identifier.orcid0000-0001-5450-5213
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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SESARAM - C - Unidade de Investigação Dr.ª Maria Isabel Mendonça