Publicação
Calcium phosphate bone substitutes in the prevention of bisphosphonate-related osteonecrosis of the jaw : a review
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Paulo, Siri | |
| dc.contributor.author | Abrantes, Ana Margarida | |
| dc.contributor.author | Laranjo, Mafalda | |
| dc.contributor.author | Marto, Carlos Miguel | |
| dc.contributor.author | Paula, Anabela | |
| dc.contributor.author | Trancoso, Pedro | |
| dc.contributor.author | Botelho, Filomena | |
| dc.contributor.author | Serra, Arménio | |
| dc.contributor.author | Ferreira, Manuel Marques | |
| dc.date.accessioned | 2026-06-02T14:05:58Z | |
| dc.date.available | 2026-06-02T14:05:58Z | |
| dc.date.issued | 2026-03 | |
| dc.description.abstract | Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is characterized by exposed necrotic bone that often progresses with increasing pain and impaired quality of life. Zoledronate, the most potent and widely used bisphosphonate, has been strongly associated with BRONJ development following invasive dental procedures. Given the rising incidence of BRONJ, understanding and implementing effective preventive strategies have become imperative. Biomaterials based on synthetic hydroxyapatite and beta-tricalcium phosphate have been investigated as potential preventive agents. Their therapeutic rationale is supported by two key principles: the well-documented chemical interaction of calcium phosphates with bisphosphonates when used as drug carriers, and the established clinical use of synthetic calcium phosphate biomaterials in dentistry for bone regeneration. This review examines the underlying mechanisms of this preventive therapeutic strategy and evaluates studies investigating synthetic calcium phosphate biomaterials for BRONJ prevention through zoledronate adsorption at jaw wound sites, thereby reducing soft tissue toxicity and promoting healing. The evidence supports the protective effect of these biomaterials as a scientifically grounded preventive approach for BRONJ. | eng |
| dc.identifier.citation | Paulo S, Abrantes AM, Laranjo M, Marto CM, Paula A, Trancoso P, Botelho F, Serra A, Ferreira MM. Calcium Phosphate Bone Substitutes in the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Review. Journal of Functional Biomaterials. 2026; 17(3):145. https://doi.org/10.3390/jfb17030145 | |
| dc.identifier.doi | 10.3390/jfb17030145 | |
| dc.identifier.issn | 2079-4983 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/63503 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/jfb17030145 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | bisphosphonates | |
| dc.subject | osteonecrosis of jaw | |
| dc.subject | prevention | |
| dc.subject | calcium phosphate | |
| dc.subject | bone substitutes | |
| dc.title | Calcium phosphate bone substitutes in the prevention of bisphosphonate-related osteonecrosis of the jaw : a review | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 3 | |
| oaire.citation.startPage | 145 | |
| oaire.citation.title | Journal of Functional Biomaterials | |
| oaire.citation.volume | 17 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |