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Publication
Células estaminais e medicina dentária: que futuro?
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| 6.25 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
Desde a sua descoberta, as células estaminais mesenquimais têm sido exaustivamente estudadas, por possuírem capacidade de auto-renovação, diferenciação em várias linhas celulares e ultrapassando os problemas éticos associado às células estaminais embrionárias. São já conhecidas algumas fontes ricas destas células, mas por vezes a sua acessibilidade encontra-se dificultada. Neste sentido, a procura por outros tipos de células mesenquimais, com características semelhantes, permanece constante.
Mais recentemente foram descobertas células estaminais mesenquimais em tecidos dentários, designadas de células estaminais dentárias, que inclui células estaminais da polpa dentária (DPSCs), células estaminais de dentes decíduos esfoliados (SHED), células estaminais da papila apical (SCAP), células estaminais do ligamento periodontal (PDLSCs) e células precursoras do folículo dentário (DFPCs).
A descoberta destas células originou um novo impulso na Engenharia de Tecidos e Terapia Celular, devido à sua facilidade de obtenção e às propriedades semelhantes, ou até mesmo melhoradas, em relação às células estaminais mesenquimais já estudadas.
Nesta revisão são abordadas as propriedades individuais de cada célula estaminal mesenquimal dentária e apresentados vários estudos que apoiam a futura aplicabilidade clínica na regeneração/reparação de tecidos orais, extra-orais e tratamento de doenças.
Since its discovery, mesenchymal stem cells have been extensively studied because they have the capacity for self-renewal, differentiation into different cell lines, and to overcome the ethical problems associated with embryonic stem cells. Some rich sources of these cells are already known, but sometimes their accessibility is hard. In this sense, the search for other types of mesenchymal cells, with similar characteristics, remains constant. More recently, mesenchymal stem cells have been discovered in dental tissues, called dental stem cells, which includes dental pulp stem cells (DPSCs), excised deciduous stem cells (SHED), apical papilla stem cells (SCAP), stem cells periodontal ligament (PDLSCs) and dental follicle precursor cells (DFPCs). The discovery of these cells gave rise to a new impulse in Tissue Engineering and Cell Therapy, due to easiness of production and similar properties, or even improved, in relation to the mesenchymal stem cells already studied. In this review, the individual properties of each dental mesenchymal stem cells are discussed and several studies presented to support the future clinical applicability in the regeneration / repair of oral, extra-oral tissues and treatment of diseases.
Since its discovery, mesenchymal stem cells have been extensively studied because they have the capacity for self-renewal, differentiation into different cell lines, and to overcome the ethical problems associated with embryonic stem cells. Some rich sources of these cells are already known, but sometimes their accessibility is hard. In this sense, the search for other types of mesenchymal cells, with similar characteristics, remains constant. More recently, mesenchymal stem cells have been discovered in dental tissues, called dental stem cells, which includes dental pulp stem cells (DPSCs), excised deciduous stem cells (SHED), apical papilla stem cells (SCAP), stem cells periodontal ligament (PDLSCs) and dental follicle precursor cells (DFPCs). The discovery of these cells gave rise to a new impulse in Tissue Engineering and Cell Therapy, due to easiness of production and similar properties, or even improved, in relation to the mesenchymal stem cells already studied. In this review, the individual properties of each dental mesenchymal stem cells are discussed and several studies presented to support the future clinical applicability in the regeneration / repair of oral, extra-oral tissues and treatment of diseases.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Células estaminais mesenquimais Células estaminais dentárias Medicina dentária regenerativa Engenharia de tecidos