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Stress, salivary cortisol and periodontitis : a systematic review and meta-analysis of observational studies

2018-12Artigo científico Acesso restrito
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dc.contributor.authorBotelho, João
dc.contributor.authorMachado, Vanessa
dc.contributor.authorMascarenhas, Paulo
dc.contributor.authorRua, João
dc.contributor.authorAlves, Ricardo
dc.contributor.authorCavacas, Maria Alzira
dc.contributor.authorDelgado, Ana
dc.contributor.authorMendes, José João
dc.date.accessioned2020-10-20T11:41:57Z
dc.date.available2020-10-20T11:41:57Z
dc.date.issued2018-12
dc.description.abstractObjective: This meta-analysis aims to systematically assess whether periodontitis has a meaningful effect on salivary cortisol, reflecting changes on free blood cortisol levels. Design: The Cochrane Handbook and the PRISMA statement were used as reporting guidelines. The MEDLINE-PubMed, Google Scholar, EMBASE, and CENTRAL databases were searched until September 2017 to identify eligible studies, screened by seven independent authors and verified by an eighth. Studies comparing salivary cortisol level of periodontitis cases to controls were included. Data were extracted using a predefined table and since all papers were non-randomized clinical trials they were appraised using Downs and Black tool. DerSimonian random effects meta-analysis was performed using OpenMetaAnalyst. Results: Six cross-sectional studies were included, with 258 participants with chronic periodontitis and 72 with aggressive periodontitis, in a total of 573 participants. Overall results showed that aggressive periodontitis patients have, on average, 53% higher salivary cortisol levels than healthy controls 1.53 (1.11–2.12). Meta-regression exploring the relationship among salivary cortisol levels and periodontal measures, i.e., periodontitis severity, showed a global neutral effect, although this result requires future confirmation due to the low power of the model. Conclusion: Observational studies results suggest that subjects with aggressive periodontitis have higher salivary cortisol levels than healthy ones or patients with chronic periodontitis. Such salivary cortisol response difference may have a negative impact on the periodontium, contributing to worse the burden of aggressive periodontitis disease. In the future, wide and well-designed longitudinal studies should be carried out in order to extensively confirm this possible effect, considering the complex nature of periodontitis and its many confounders factors that may contribute to this outcome.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBotelho J, Machado V, Mascarenhas P, Rua J, Alves R, cavacas MA, Delgado A, Mendes JJ. Stress, salivary cortisol and periodontitis: A systematic review and meta-analysis of observational studies. Archives of Oral Biology, 2018 (96):58-65. DOI 10.1016/j.archoralbio.2018.08.016pt_PT
dc.identifier.doi10.1016/j.archoralbio.2018.08.016pt_PT
dc.identifier.issn0003-9969
dc.identifier.urihttp://hdl.handle.net/10400.26/33673
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.archoralbio.2018.08.016pt_PT
dc.subjectPeriodontal diseasept_PT
dc.subjectSalivary cortisolpt_PT
dc.subjectStresspt_PT
dc.subjectSystematic reviewpt_PT
dc.subjectMeta-analysispt_PT
dc.titleStress, salivary cortisol and periodontitis : a systematic review and meta-analysis of observational studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage65pt_PT
oaire.citation.startPage58pt_PT
oaire.citation.titleArchives of Oral Biologypt_PT
oaire.citation.volume96pt_PT
rcaap.embargofctPolítica de copyright do editorpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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