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Miniaturised extraction techniques in personalised medicine: analytical opportunities and translational perspectives.

2025-10-31Artigo científico Acesso aberto
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dc.contributor.authorRosendo, Luana M
dc.contributor.authorRosado, Tiago
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2026-01-30T15:48:42Z
dc.date.available2026-01-30T15:48:42Z
dc.date.issued2025-10-31
dc.description.abstractMiniaturised sampling and extraction are redefining therapeutic drug monitoring (TDM) by enabling low-volume sampling, simplifying collection, and improving patient acceptability, while also promoting decentralised workflows and more sustainable laboratory practices. This review critically appraises the current landscape, with emphasis on analytical performance, matrix compatibility, and readiness for clinical implementation. It examines validation requirements, the extent of alignment and existing gaps across major regulatory guidelines, and recurrent challenges such as haematocrit bias, real-world stability and transport, incurred sample reanalysis, device variability, commutability with conventional matrices, and inter-laboratory reproducibility. To make the evidence actionable, operational recommendations are distilled into a practical ten-point checklist designed to support validation and translation of miniaturised approaches into routine laboratory practice. Looking ahead, priorities include automation and portable platforms, advanced functional materials, and integration with digital tools and biosensors, alongside the development of harmonised frameworks tailored to miniaturised methods and prospective clinical studies that demonstrate impact on dosing decisions, adherence, and clinical outcomes. Overall, this review aims to equip researchers, laboratory professionals, and regulators with the knowledge to implement miniaturised bioanalysis and advance personalised medicine through TDM.
dc.identifier.citationRosendo, L. M., Rosado, T., Barroso, M., & Gallardo, E. (2025). Miniaturised Extraction Techniques in Personalised Medicine: Analytical Opportunities and Translational Perspectives. Molecules (Basel, Switzerland), 30(21), 4263. https://doi.org/10.3390/molecules302142
dc.identifier.doi10.3390/molecules30214263
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.26/61345
dc.language.isoen
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbioanalysis
dc.subjectbiological fluids
dc.subjectdrug monitoring
dc.subjectminiaturised extraction techniques
dc.subjectvalidation
dc.titleMiniaturised extraction techniques in personalised medicine: analytical opportunities and translational perspectives.eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.citation.issue21
oaire.citation.titleMolecules
oaire.citation.volume30
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBarroso
person.givenNameMário
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.orcid0000-0001-8848-2734
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication294b555e-48c4-4013-b981-b8917400c56c
relation.isAuthorOfPublication.latestForDiscovery294b555e-48c4-4013-b981-b8917400c56c
relation.isProjectOfPublication4ca3c3c9-1802-4c7f-8730-9547236896fe
relation.isProjectOfPublication56ce2e5c-35e5-4eb7-8152-2e87e77f638c
relation.isProjectOfPublication.latestForDiscovery4ca3c3c9-1802-4c7f-8730-9547236896fe

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