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Nanotecnologia e sua aplicação em terapêutica oncológica
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| 1.43 MB | Adobe PDF |
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Abstract(s)
A nanotecnologia e as suas aplicações em terapêutica oncológica têm despertado o interesse da comunidade científica. O cancro é um dos problemas globais mais difíceis e complexos de abordar, com taxas de mortalidade elevadas, e para o qual a prática clínica atual se revela insuficiente. Apesar do elevado número de opções terapêuticas, o problema reside na falta de especificidade e inerente toxicidade sistémica a que os doentes estão sujeitos, o que se traduz em taxas de sucesso variáveis e pode implicar elevados níveis de desgaste físico e emocional.
Com a evolução da nanotecnologia inicia-se uma nova era de veiculação de fármacos, que utiliza as características favoráveis e únicas das nanopartículas para melhorar a terapêutica oncológica. No entanto, enfrentam também múltiplos desafios e constante ceticismo sobre o seu verdadeiro valor terapêutico.
O objetivo desta revisão de literatura é dar a conhecer os conceitos de nanotecnologia e nanomedicina, quais as principais nanoplataformas e respetivas vantagens, os benefícios desta abordagem, os progressos obtidos na prática clínica e quais os principais obstáculos que a vertente “nano” enfrenta.
Nanotechnology and its applications in cancer therapy, has sparked the interest of the scientific community. Cancer remains one of the most difficult and complex global problems to tackle, with high mortality rates, and the current clinical practice is inadequate. Despite the large number of therapeutic options, the problem lies on the lack of specificity and inherent systemic toxicity of current drugs, which translates into variable success rates and may involve high levels of physical and emotional exhaustion for patients. With the evolution of nanotechnology, a new era of drug delivery begins, using the unique and favorable characteristics of nanoparticles to improve cancer therapy. However, they also face numerous challenges and constant skepticism about their true therapeutic value. The goal of this literature review is to introduce the concepts of nanotechnology and nanomedicine, what are the main nanoplatforms and its advantages, the benefits of this approach, the advances obtained in clinical practice and the main obstacles faced by the “nano” dimension.
Nanotechnology and its applications in cancer therapy, has sparked the interest of the scientific community. Cancer remains one of the most difficult and complex global problems to tackle, with high mortality rates, and the current clinical practice is inadequate. Despite the large number of therapeutic options, the problem lies on the lack of specificity and inherent systemic toxicity of current drugs, which translates into variable success rates and may involve high levels of physical and emotional exhaustion for patients. With the evolution of nanotechnology, a new era of drug delivery begins, using the unique and favorable characteristics of nanoparticles to improve cancer therapy. However, they also face numerous challenges and constant skepticism about their true therapeutic value. The goal of this literature review is to introduce the concepts of nanotechnology and nanomedicine, what are the main nanoplatforms and its advantages, the benefits of this approach, the advances obtained in clinical practice and the main obstacles faced by the “nano” dimension.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Nanotecnologia Nanomedicina Cancro Terapêutica oncológica